Publications by authors named "Vilma Lagebro"
Article Synopsis
- OSCC recurrence and mortality rates remain high despite various treatments, highlighting the need for improved prognostic models and biomarkers, particularly focusing on tumor-draining lymph nodes (TDLNs) and T regulatory cells (Tregs).
- A study of 49 OSCC patients found that certain immune cell markers in TDLNs, like elevated FoxP3+CD4+ and TIGIT+CD8+ cells, were linked to worse disease-free survival, while high levels of CXCR5+CD4+ cells indicated better outcomes.
- The research suggests that the expression of immune checkpoints on T cells within TDLNs could serve as critical prognostic biomarkers, pointing towards the potential benefits of using neoadjuvant immunotherapy to enhance
Article Synopsis
- Oral squamous cell carcinoma (OSCC) has a better survival rate when detected early, but prognosis worsens if it spreads to lymph nodes; identifying biomarkers for early detection could improve treatment strategies.
- The study analyzed dendritic cells and T-cells in tumor-draining lymph nodes from 12 OSCC patients and compared them to 9 benign cases, revealing that certain immune cells in TDLNs show immunosuppressive characteristics and are linked to metastasis.
- Findings suggest that high PD-L1 expression on dendritic cells in TDLNs may indicate metastatic risk and poorer outcomes, positioning PD-L1 as a potential predictive biomarker for OSCC prognosis.
Cutaneous squamous cell cancer (cSCC) is the second most common form of skin cancer, characterized by abnormal, accelerated growth of squamous cells. When caught early, most cSCCs are curable. About 5 percent of the cSCC cases have advanced to such an extent, generally metastatic, that they are far more dangerous, with very poor prognosis and challenging to treat.
View Article and Find Full Text PDFBackground: Allergic asthma is a heterogeneous disorder involving chronic airway inflammation, reversible airflow limitation, and tissue remodeling, causing chronic airflow limitation. Most of the asthma research has been focused on elucidating the proinflammatory pathways underlying disease pathogenesis. Paradoxically, the necessity of appropriate termination and resolution of inflammation has not been recognized until recently.
View Article and Find Full Text PDFThe contribution of different immune cell subsets, especially T cells, in anti-tumor immune response is well established. In contrast to T cells, the anti-tumor contribution of B cells has been scarcely investigated. B-cells are often overlooked, even though they are important players in a fully integrated immune response and constitute a substantial fraction of tumor draining lymph nodes (TDLNs) known also as Sentinel Nodes.
View Article and Find Full Text PDFIntroduction: High Tregs infiltration within the tumour microenvironment (TME) of various cancers shows a positive correlation with poor prognosis. Despite the fact that tumour draining lymph nodes (TDLNs) are recognized as key organs playing a crucial role in response to immunotherapy and modulating anti-cancer immunity, the distribution of Tregs and their role in TDLNs remain uncertain thus far. The purpose of this project is to investigate the density of Tregs in TDLNs and non-TDLNs and their expression of immune checkpoint molecules - PD-1 and CTLA-4.
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