Publications by authors named "Vilma Gladys Duschak"
Article Synopsis
- Arginine kinase (AK) is an enzyme linked to allergic reactions in invertebrates and is also present in the parasite T. cruzi, which causes Chagas disease.
- The study investigated the presence of specific antibodies against T. cruzi AK (TcAK) in patients with chronic Chagas disease (CCD) and found differing levels of IgG and IgE antibodies between infected and non-infected individuals.
- Results suggest that TcAK might play a role in influencing B cell responses and could contribute to allergic reactions during T. cruzi infection, revealing a potential new target for understanding immune responses in affected patients.
Trypanosoma cruzi, the agent of Chagas disease contains a major cysteine proteinase, cruzipain (Cz), with an unusual carboxyl-terminal extension (C-T). We have previously reported the presence of sulfate groups in the N-linked oligosaccharide chains of this domain. In order to evaluate the immune responses to sulfated moieties on Cz, BALB/c mice were immunized with purified Cz and C-T prior and after desulfation treatment.
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