Publications by authors named "Villumsen B"
European S2k guidelines for hidradenitis suppurativa/acne inversa part 2: Treatment.
J Eur Acad Dermatol Venereol
December 2024
Introduction: This second part of the S2k guidelines is an update of the 2015 S1 European guidelines.
Objective: These guidelines aim to provide an accepted decision aid for the selection, implementation and assessment of appropriate and sufficient therapy for patients with hidradenitis suppurativa/acne inversa (HS).
Methods: The chapters have been selected after a Delphi procedure among the experts/authors.
This review describes that a core outcome set (COS) represents a consensus-based minimum set of outcomes to be collected and reported in clinical trials involving a particular disease or population. A COS serves as a guideline for global consensus on which outcome domains should be collected in all clinical trials. After defining what to measure, it becomes crucial to reach consensus on how to measure it.
View Article and Find Full Text PDF"What matters to you" on the day of surgery: Protocol for a mixed methods study.
Acta Anaesthesiol Scand
September 2024
Article Synopsis
- Patients often experience significant fear and anxiety about anesthesia and surgery, highlighting the need for better understanding and addressing their emotional needs.
- This study aims to investigate patients' concerns, perceived worry, and fear related to surgery by directly asking them on the day of their procedure.
- The research utilizes a mixed methods approach, combining qualitative and quantitative data from surveys completed by patients in perioperative departments across Denmark during the "What Matters To You" Day in June 2024.
Article Synopsis
- The global burden of hidradenitis suppurativa (HS) is poorly understood due to limited and varying prevalence data, which has been affected by different methodologies and diagnostic approaches.
- The Global Hidradenitis Suppurativa Atlas (GHiSA) aims to accurately determine HS prevalence by using a validated questionnaire for screening, followed by physician validation for positive cases, assessing about 10% of negatives for diagnostic accuracy.
- Currently, GHiSA is conducting prevalence studies in 58 countries to create a comprehensive global prevalence estimate through proportional meta-analysis, allowing for direct international comparisons that were not previously feasible.
Article Synopsis
- There are existing registries for hidradenitis suppurativa (HS) in Europe and the USA, but there is no global standard on the data collected, which complicates international collaboration.
- The goal is to create a core dataset (CDS) for global HS registries covering demographics, comorbidities, clinical findings, patient outcomes, and treatments.
- A Delphi process involving 20 experts from eight countries resulted in a consensus on 48 items to be included in all HS registries, promoting consistent data collection worldwide.
Article Synopsis
- Androgen deprivation therapy (ADT) can negatively impact metabolic health, affecting insulin sensitivity and levels of certain hormones in men with prostate cancer.
- A study with 46 patients compared the effects of a 12-week unsupervised home exercise program (exergaming) against usual care on various health markers.
- Results showed significant improvements in triglycerides and HDL cholesterol for the exercise group, suggesting exergaming might help combat cardiovascular risks associated with ADT.
In clinical studies, beneficial and harmful effects of interventions are investigated by measuring predefined outcomes. The uncontrolled choice of these outcomes carries a risk of outcome reporting bias, large heterogeneity of outcomes with reduced options for evidence synthesis. Furthermore, such outcomes may not be important for stakeholders including patients.
View Article and Find Full Text PDFHidradenitis suppurativa (HS) is a chronic inflammatory skin disease associated with psychiatric comorbidity. Attention deficit hyperactivity disorder (ADHD) is a mental disorder associated with systemic and skin inflammation such as psoriasis and atopic dermatitis. Whether HS symptoms are associated with ADHD symptoms remains unexplored.
View Article and Find Full Text PDFDrainage from chronic wounds can significantly negatively impact a patient's quality of life. Change in severity of wound drainage is an important measure of treatment efficacy for wounds. This study reviews existing tools used to assess wound drainage.
View Article and Find Full Text PDFBackground: Nearly half of patients with hidradenitis suppurativa (HS) report dissatisfaction with their treatment. However, factors related to treatment satisfaction have not been explored.
Objectives: To measure associations between treatment satisfaction and clinical and treatment-related characteristics among patients with HS.
Background: Few validated instruments exist for use in hidradenitis suppurativa (HS) trials.
Objectives: To develop a novel HS Investigator Global Assessment (HS-IGA) and to validate its psychometric properties.
Methods: Development of HS-IGA involved discussion among stakeholders, including patients, within HISTORIC.
Supervised exercise therapy compared with no exercise therapy to reverse debilitating effects of androgen deprivation therapy in patients with prostate cancer: a systematic review and meta-analysis.
Prostate Cancer Prostatic Dis
September 2022
Background: Androgen deprivation therapy (ADT) in patients with prostate cancer can have several debilitating side effects. Supervised exercise is recommended to ameliorate these negative effects.
Objective: To systematically evaluate the effect of supervised exercise therapy compared to no exercise therapy in patients with prostate cancer undergoing ADT, primarily according to the patient critical outcomes, 'disease-specific quality of life' and 'walking performance' measured at end of treatment.
Background: Hidradenitis suppurativa (HS) is a chronic inflammatory disease. The HS core outcome set calls for a patient global assessment (PtGA).
Objectives: To assess the validity, reliability and responsiveness of a candidate single-item PtGA for HS-specific health-related quality of life (HRQoL).
Background: Hidradenitis suppurativa (HS) is a chronic, inflammatory condition that can have a large negative impact on health-related quality of life (HRQOL). A reliable and validated measure of HS-specific HRQOL in clinical studies is needed.
Objectives: To develop and validate the Hidradenitis Suppurativa Quality Of Life (HiSQOL©) scale, for clinical trial measurement of HS-specific HRQOL.
Background: A needs assessment for patients with hidradenitis suppurativa (HS) will support advancements in multidisciplinary care, treatment, research, advocacy, and philanthropy.
Objective: To evaluate unmet needs from the perspective of HS patients.
Methods: Prospective multinational survey of patients between October 2017 and July 2018.
Article Synopsis
- The study aimed to investigate the impact of 12 weeks of unsupervised home-based exergaming on patients with prostate cancer receiving androgen-deprivation therapy compared to usual care.
- Significant improvements were observed in the primary outcome of the 6-minute walking test for the exergaming group, but no notable differences in secondary outcomes like leg extensor power, body composition, quality of life, or fatigue were found.
- Overall, exergaming proved beneficial for walking ability and is suggested as a safe alternative to standard exercise methods for this population.
Background: There is no consensus on core outcome domains for hidradenitis suppurativa (HS). Heterogeneous outcome measure instruments in clinical trials likely leads to outcome-reporting bias and limits the ability to synthesize evidence.
Objectives: To achieve global multistakeholder consensus on a core outcome set (COS) of domains regarding what to measure in clinical trials for HS.
Background: A core outcomes set (COS) is an agreed minimum set of outcomes that should be measured and reported in all clinical trials for a specific condition. Hidradenitis suppurativa (HS) has no agreed-upon COS. A central aspect in the COS development process is to identify a set of candidate outcome domains from a long list of items.
View Article and Find Full Text PDFIntroduction: Randomised controlled trials (RCTs) should have well-defined primary and secondary outcomes to answer questions generated by the main hypotheses. However, for the chronic, inflammatory skin disease hidradenitis suppurativa (HS), the reported outcome measures are numerous and diverse. A recent systematic review found a total of 30 outcome measure instruments in 12 RCTs.
View Article and Find Full Text PDFCentriolar satellites (CS) are small granular structures that cluster in the vicinity of centrosomes. CS are highly susceptible to stress stimuli, triggering abrupt displacement of key CS factors. Here we discover a linear p38-MK2-14-3-3 signalling pathway that specifically targets CEP131 to trigger CS remodelling after cell stress.
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