Publications by authors named "Villeret J"
Article Synopsis
- Vaginal/cervical clear cell adenocarcinoma (CCAC) has not previously been reported in granddaughters of women treated with diethylstilbestrol (DES) during pregnancy.
- An 8-year-old girl diagnosed with cervical CCAC underwent fertility-sparing surgery and radiotherapy, with no recurrence noted after 10 years.
- While a direct causal link hasn't been established, this case suggests potential multigenerational effects of DES and highlights the importance of monitoring granddaughters of DES-treated women.
[Differential diagnosis of basal cell carcinoma of the face: Dermatologist advice may avoid surgery].
Rev Stomatol Chir Maxillofac Chir Orale
November 2016
Introduction: Basal cell carcinoma (BCC) is the most common skin cancer in France. It is commonly diagnosed in front of a papule or nodule of the face. The surgeon should be able to question the diagnosis of BCC when nodular lesions are untypical, keeping in mind that some differential diagnoses require only medical treatment.
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- The study aimed to evaluate if using direct colposcopic vision (DCV) during LLETZ affects specimen size and margin status in cervical cancer treatment.
- It involved 216 women undergoing LLETZ for cervical intraepithelial neoplasia, comparing outcomes across three groups based on colposcopy usage.
- Results showed that specimens from the DCV group were significantly smaller in volume and dimensions, while margin status remained unaffected, indicating DCV may improve surgical outcomes without compromising quality.
Article Synopsis
- The study aimed to determine if using direct colposcopic vision during the excision of cervical intraepithelial neoplasia (CIN) affects treatment failure rates.
- Researchers reviewed data from 285 CIN patients and found that while the excised specimens were smaller with direct colposcopy, this did not significantly influence the risk of treatment failure.
- The only factors significantly affecting treatment outcomes were having clear margins during surgery and the size of the excised specimen.
Article Synopsis
- This study investigates the relationship between high-risk HPV DNA testing, viral load, and E6/E7 mRNA detection to understand their correlation with the severity of cervical lesions.
- Out of 151 cervical specimens analyzed, HPV DNA was present in 57.6% of samples, with detection rates increasing from normal tissue to cancerous tissue, while E6/E7 mRNA was found in 43% of samples, also showing an increase alongside lesion severity.
- The study reveals that both HPV DNA and E6/E7 mRNA detection rates are significantly higher in more severe cervical lesions, indicating that these markers can potentially serve as indicators of cervical cancer progression.
We report here the clinical case of an Afro-Caribbean patient referred for complete atrioventricular block for whom a diagnosis of hereditary cardiac amyloidosis was eventually confirmed. Hereditary cardiac amyloidosis is an emerging threat in the Caribbean, and the main goal of this report is to raise the awareness of the disease among physicians.
View Article and Find Full Text PDFObjective: To perform a head to head comparison of these two nomograms by an external validation combined with an identification of probability cut-offs when to indicate NS.
Methods: The full models of the nomograms of Ohori et al. and Steuber et al.
Background: The amplification of epidermal growth factor receptor (EGFR) in triple negative breast carcinomas (TNBC) suggests its potential therapeutic application, as for HER-2, using standardised methods of measurement. In this regard, we aimed to compare several methods for evaluating EGFR amplification along with potential mutations for suitability in clinical practice.
Methods: Tissue sections of 138 TNBCs were used (1) to compare EGFR amplification and expression by silver in situ hybridisation (SISH) to qPCR and immunohistochemistry (IHC) and (2) to search for EGFR mutations, along with Kras, PI3K, Braf and HER-2 mutations and echinoderm microtubule associated protein like 4-anaplastic lymphoma kinase (EML4-ALK) translocation.
Article Synopsis
- Mesenteric panniculitis is a rare chronic inflammatory disease affecting fatty tissue in the mesentery of the intestines, with unclear pathology and possible links to other diseases.
- A case study of a 64-year-old man presented symptoms like abdominal pain and weight loss, and imaging suggested the presence of mesocolic panniculitis, confirmed by histological analysis after laparoscopic surgery.
- The patient improved with supportive care alone, highlighting that while mesenteric panniculitis can sometimes have serious symptoms, it is often diagnosed through imaging and can have a positive prognosis with minimal treatment.
Article Synopsis
- - Recent research validated a predictive immunohistochemical (IHC) assay for breast cancer outcomes using tumor samples from two universities, Marseille and Yale, involving a total of 721 patients.
- - The study focused on 15 specific biomarkers and found that a combination of five markers (HIF-1α, PI3K, claudin-1, AF6, and pAKT) accurately predicted patient outcomes in 92.34% and 89.8% of cases from the Marseille and Yale cohorts, respectively.
- - The findings suggest the potential for standardized testing in clinical practice to help identify node-negative breast cancer patients at high risk for poor outcomes, enabling more tailored treatment strategies.
We present the case of a pelvic schwannoma in a 36 year old man. It was discovered by chance during the medical assessment of a prostatitis. A computed tomography scan and magnetic resonance imaging revealed a 8 centimeters cystic pelvic tumor, closed to the right seminal vesicle.
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