Epinephrine Versus Dopamine in Children, What Is the Current Evidence and What Do We Need? A Systematic Review and Meta-analysis.

Introduction: Pediatric patients often receive vasoactive agents following cardiothoracic surgery or when in shock. The use of vasoactive agents varies between different settings and has largely changed because of anecdotal observations or small observational studies. Although vasoactive agents are frequently used, there are limited studies in pediatric populations comparing them to one another.

The Effect of Combined Strength, Plyometric, and Sprint Training on Repeated Sprint Ability in Team-Sport Athletes: A Systematic Review and Meta-Analysis.

Repeated sprint ability (RSA) is crucial for success in team sports, and involves both neuromuscular and metabolic factors. While single-mode training (SGL; e.g.

Nonsteroidal Anti-Inflammatory Drugs Decrease Coagulopathy Incidence in Severe Burn Patients.

The study investigated the impact of nonsteroidal anti-inflammatory drugs (NSAIDs) on burn-induced coagulopathy in severely burned patients. Patients with a greater than 20% TBSA were identified in the TriNetX research network and categorized into receiving or not receiving NSAIDs in the first week after the burn. The statistical significance of the rate of burn-induced coagulopathy, mortality and sepsis in the week following injury was analysed.

Poor correlation of venous lactate with systemic oxygen saturation in the paediatric cardiac ICU: a pilot study.

Introduction: Cardiac intensive care providers require a comprehensive understanding of cardiac output and oxygen delivery. The estimation of cardiac output in clinical practice often relies on thermodilution and the Fick principle. Central venous saturation and lactate levels are commonly used indicators for cardiac output assessment.

Mechanisms of lung endothelial cell injury and survival in pulmonary arterial hypertension.

Pulmonary arterial hypertension (PAH) is a progressive, chronic, and incurable inflammatory pulmonary vascular disease characterized by significant sex bias and largely unexplored microbial-associated molecular mechanisms that may influence its development and sex prevalence across various subgroups. PAH can be subclassified as idiopathic, heritable, or associated with conditions such as connective tissue diseases, congenital heart defects, liver disease, infections, and chronic exposure to drugs or toxins. During PAH progression, lung vascular endothelial cells (ECs) undergo dramatic morphofunctional transformations in response to acute and chronic inflammation.

Sex and Gender Differences in Alzheimer's Disease: Genetic, Hormonal, and Inflammation Impacts.

Two-thirds of Americans with Alzheimer's disease are women, indicating a profound variance between the sexes. Variances exist between the sexes in the age and intensity of the presentation, cognitive deficits, neuroinflammatory factors, structural and functional brain changes, as well as psychosocial and cultural circumstances. Herein, we summarize the existing evidence for sexual dimorphism and present the available evidence for these distinctions.

The importance of genetic counselling for turner syndrome transition.

The healthcare transition (HCT) is the process of planning, monitoring, and adjusting the clinical management from children's care to adult specialists. Although this practice is common for all children, it is especially crucial (and challenging) for those with chronic disorders and genetic conditions that also involve mental health issues, requiring a multidisciplinary approach. In this review, we aim to assess the current status of transition for girls and young women with Turner syndrome (TS) as a model as it is one of the most common sexual chromosomal aneuploidies.

Perceptions and use of recovery strategies in water polo players and coaches: a worldwide survey.

The objective of this study was to assess the perceived usefulness, actual use and limitations for the application of recovery strategies among water polo (WP) players and their coaches around the world. A total of 231 WP players and 76 coaches representing all continents, both genders and all levels of competition, completed a freely accessible online survey. This was divided into three sections: sociodemographic data (8 questions), importance of perceived usefulness of recovery strategies (3 questions), and actual use of recovery methods (6 questions).

Factors associated with renal oxygen extraction in mechanically ventilated children after the Norwood operation: insights from high fidelity haemodynamic data.

Background: Maintaining the adequacy of systemic oxygen delivery is of utmost importance, particularly in critically ill children. Renal oxygen extraction can be utilised as metric of the balance between systemic oxygen delivery and oxygen consumption. The primary aim of this study was to determine what clinical factors are associated with renal oxygen extraction in children after Norwood procedure.

Congenital mixed hiatal hernia: A case report of an atypical cause of neonatal vomiting.

Congenital mixed hiatal hernia is a disorder that combines features of both sliding and paraoesophageal hernias. The precise incidence of congenital mixed hiatal hernia during the pediatric and neonatal period remains uncertain, making diagnosis challenging within this age cohort. This case presents a 15-day-old female with an 8% postnatal weight loss and apost-feeding vomiting.

Pediatric tuberculosis in Mexico: A retrospective analysis of 100 patients.

Background: Analyzing the epidemiology and clinical manifestations of pediatric tuberculosis in endemic regions is crucial to meet the goal of ending tuberculosis. The objective was to assess the various clinical scenarios of tuberculosis in a large pediatric cohort in Mexico.

Methods: This retrospective study from a pediatric referral center in Mexico included patients diagnosed with tuberculosis from 2012 to 2021.

Estimation of the inferior caval vein saturation using high-fidelity non-invasive haemodynamic values and validation of modelled estimates.

Objectives: Monitoring venous saturation allows identification of inadequate systemic oxygen delivery. The aim was to develop a model using non-invasive haemodynamic variables to estimate the inferior caval vein saturation and to determine its prognostic utility.

Methods: This is a single-centre, retrospective study.

Postoperative Atrioventricular Block in Pediatric Patients: Impact of Congenital Cardiac Malformations and Medications.

Postoperative atrioventricular block may occur after pediatric cardiac surgery. A small proportion of those who develop atrioventricular block will require pacemaker placement. The primary aim of this study was to determine factors associated with postoperative atrioventricular block.

The Utilisation of INR to identify coagulopathy in burn patients.

Studies conflict on the significance of burn-induced coagulopathy. We posit that burn-induced coagulopathy is associated with injury severity in burns. Our purpose was to characterize coagulopathy profiles in burns and determine relationships between % total burn surface area (TBSA) burned and coagulopathy using the International Normalized Ratio (INR).

Effects of Sand Surface Plyometric and Sprint Training on Physical and Technical Skill Performance in Beach Handball Players.

This study compared the effects of a 6-week combined plyometric and sprint-training program on the sand to regular preseason training, on the athletic performance and technical actions of beach handball (BH) players. Athletes were randomly assigned either to the control (CG, n = 12; BH training only) or the experimental group (EG, n = 12; plyometric + sprint + BH training). Assessments conducted before and after the training period included a squat jump, a countermovement jump, the Abalakov jump, a 15-m sprint, a modified Course-Navette endurance test, and four sport-specific BH throwing speed tests: a standing penalty throw, a 3-step running throw, a jump throw, and a 360º jump throw.

Antepartum Psychosis in the Setting of Preeclampsia With Severe Features: A Case Report.

The peripartum period, which can be further delineated into postpartum and antepartum periods, poses a heightened risk for psychiatric symptoms. While much is known about the risk of psychiatric symptoms in the postpartum period, antepartum psychosis remains exceedingly rare and poorly understood. This report presents a unique case of a 34-year-old pregnant woman with a past psychiatric history significant for recurrent major depressive disorder, generalized anxiety disorder, and substance use disorder of alcohol and marijuana, who developed preeclampsia with severe features and acute psychosis during the antepartum period.

Thermal Profiles in Water Injection Wells: Reduction in the Systematic Error of Flow Measurements during the Transient Regime.

This article presents an analytical solution for calculating the flow rate in water injection wells based on the established thermal profile along the tubing. The intent is to minimize the intrinsic systematic error of classic quasi-static methodologies, which assume that all thermal transience on well completion has passed. When these techniques are applied during the initial hours of injection well operation, it can result in errors higher than 20%.

XEN45 Gel Stent Combined with Healaflow Injectable Viscoelastic Implant.

Purpose: To introduce a potential solution for failed glaucoma surgeries by proposing an optional surgical procedure in conjunction with the use of Healaflow (Anteis S.A., Geneva, Switzerland) as a spacer, which may potentially reduce the failure rate.

Correlation of hepatic venous saturation and mixed venous saturation: pooled analyses.

Introduction: In critical care, monitoring adequate tissue oxygenation is essential. Mixed venous oxygen saturation has traditionally been considered the gold standard for measuring cardiac output, which represents systemic oxygen delivery. Studies have shown that hepatic vein saturation is correlated with mixed venous oxygen saturation and mortality.