Publications by authors named "Villaret D"
Background: We report the University of Florida experience with soft-palate carcinoma treated with radiotherapy alone or combined with adjuvant chemotherapy and/or neck dissection for residual disease in the neck.
Methods: A total of 145 patients treated with curative intent from 1963 to 2004 were included. Potential follow-up was > or =2 years.
Background: Clear cell odontogenic carcinoma (CCOC) is a rare tumor of odontogenic origin. It was first described as a clinicopathological entity in 1985, and since then, several case reports have been published.
Methods: We present a patient with CCOC treated at the University of Florida and review the pertinent literature.
Objectives/hypothesis: This article presents a case of a patient with follicular dendritic cell sarcoma (FDS), a rare neoplasm usually of the head and neck, and reviews the literature.
Study Design: Literature review.
Methods: A MEDLINE literature search was performed and the literature was reviewed.
Background: The purpose was to determine if postradiotherapy (RT) neck dissection can be limited to the neck levels of residual adenopathy on post-RT computed tomography (CT).
Methods: In all, 274 patients with lymph node-positive head and neck squamous cell carcinoma were treated with definitive RT. All patients had a contrast-enhanced CT performed 4 weeks after completing RT to evaluate tumor response.
The management of head and neck cancer has evolved into a multidisciplinary approach in which patients are evaluated before treatment and decisions depend on prospective multi-institutional trials, as well as retrospective outcome studies. The choice of one or more modalities to use in a given case varies with the tumor site and extent, as exemplified in the treatment of laryngeal squamous cell carcinomas. The goals of treatment include cure, laryngeal voice preservation, voice quality, optimal swallowing, and minimal xerostomia.
View Article and Find Full Text PDFPurpose: To discuss the treatment and outcomes of inverted papilloma of the nasal cavity and paranasal sinuses.
Methods: Review of the pertinent literature.
Results: Inverted papilloma is a benign, locally aggressive neoplasm that arises in the nasal cavity and is associated with squamous cell carcinoma in approximately 5% of patients.
Purpose: The purpose of this study was to report the outcomes after external-beam radiotherapy (RT) for selected T3 and T4 vocal cord squamous cell carcinomas.
Methods And Materials: One hundred nine patients with previously untreated T3 and T4 squamous cell carcinomas of the glottic larynx were treated with curative intent in this Institutional Review Board-approved outcome study using continuous-course RT alone (106 patients) or followed by a planned neck dissection (3 patients) between September 1966 and June 2002. Patients selected for such treatment had relatively low-volume, unilateral disease.
Perineural invasion occurs in 2% to 6% of cutaneous basal and squamous cell carcinomas of the head and neck and is associated with midface location, recurrent tumors, high histologic grade, and increasing tumor size. Patients may be asymptomatic with perineural invasion appreciated on pathologic examination of the surgical specimen (incidental) or may present with cranial nerve deficits (clinical). The cranial nerves most commonly involved are the 5th and 7th nerves.
View Article and Find Full Text PDFBackground: The role of salvage neck dissection for isolated regional recurrences after definitive radiotherapy (RT) is ill-defined.
Methods: Five-hundred fifty patients were treated with RT for lymph node-positive head and neck cancer. RT consisted of a median dose of 74.
Objective: To determine the rates of local-regional control, survival, and complications for patients treated with postoperative radiation for squamous carcinomas of the larynx, hypopharynx, and oropharynx.
Methods: There were 295 patients with previously untreated squamous cell carcinomas of the larynx (n = 199), hypopharynx (n = 80), and oropharynx (n = 16) treated postoperatively with radiotherapy (RT).
Results: Five-year local-regional control rates according to site and pathologic American Joint Committee on Cancer (AJCC) stage were: stage III larynx, 89% versus stage IVA larynx, 85% (P = 0.
This review discusses the role of postoperative radiotherapy (RT) for patients with squamous cell carcinoma of the head and neck. Patients with unfavorable pathologic features have a high-risk of local-regional recurrence and a decreased likelihood of survival after surgery alone. Postoperative RT reduces the risk of local-regional failure and probably improves survival.
View Article and Find Full Text PDFPurpose: The purpose of this study is to update our experience with definitive radiotherapy (RT) for carcinoma of the tonsillar area.
Patients And Methods: There were 503 patients treated between October 1964 and May 2003 (potential follow-up for at least 2 years). Of these, 198 patients underwent a planned neck dissection and 57 patients received induction (18 patients) or concomitant (39 patients) chemotherapy.
Purpose: To determine how to use node response on computed tomography (CT) to indicate the need for neck dissection.
Patients And Methods: Five hundred fifty patients with lymph node-positive head and neck cancer were treated between 1990 and 2002 with radiotherapy (RT) at a median dose of 74.4 Gy; 24% of these patients (n = 133) were treated with chemotherapy.
Objective: To evaluate definitive radiotherapy (RT) for treatment of base of tongue cancer.
Methods: There were 333 patients with squamous cell carcinoma of the base of tongue treated with definitive RT and had follow-up from 0.2 to 26.
Purpose: The purpose of this paper is to discuss the treatment and outcomes for patients with sinonasal undifferentiated carcinoma.
Methods: Review of the pertinent literature.
Results: Most series contain a limited number of patients treated with various combinations of surgery, radiotherapy (RT), and chemotherapy.
Purpose: To evaluate the efficacy of external beam radiation therapy (EBRT) for differentiated thyroid carcinomas.
Methods: Forty-two patients with a locally advanced or recurrent differentiated thyroid carcinoma received high-dose EBRT. Thirty-three patients had local-regional disease and 9 patients also had asymptomatic disease metastases.
Purpose: The purpose of this article is to discuss the optimal treatment and outcomes for head and neck mucosal melanoma.
Methods: Review the pertinent literature.
Results: Head and neck mucosal melanoma is a rare entity comprising less than 1% for all Western melanomas.
Purpose: To analyze the outcomes of adult patients with head and neck soft tissue sarcomas.
Methods: Review of 39 patients treated with radiotherapy (RT) alone (6 patients) or combined with surgery (33 patients) with curative intent between December 1966 and February 2003. Follow-up for living patients ranged from 1 to 21 years (median, 8.
Background: The authors analyzed the outcomes of patients treated with radiotherapy (RT) alone or combined with surgery for carcinoma of the salivary glands.
Methods: Between October 1964 and June 2003, 224 previously untreated patients were treated with curative intent with RT alone (n = 64) or combined with surgery (n = 160) at the University of Florida College of Medicine (Gainesville, FL). The median follow-up period was 5.
Background: Treatment outcomes were analyzed for retromolar trigone squamous cell carcinoma.
Methods: Between June 1966 and August 2003, 99 patients were treated with radiotherapy alone (35 patients) or radiotherapy combined with surgery (64 patients). Followup ranged from 0.
Objectives/hypothesis: To examine gene expression profiles in squamous cell carcinoma of the oral cavity (oral SCC) compared with histologically matched normal tissue.
Study Design: Fresh-frozen tissue was prospectively obtained from individuals undergoing surgical resections for oral SCC.
Methods: RNA was extracted from seven sets of oral SCC and matched normal tissue.
Purpose: Our purpose was to discuss the optimal treatment and outcomes for patients with skull base chordomas.
Methods: We reviewed the pertinent literature for this study.
Results: Skull base chordomas usually arise in the clivus and are rarely completely resectable.
Background: The purpose of this study was to analyze factors influencing outcome in patients who received postoperative irradiation for advanced squamous cell carcinoma of the oral cavity.
Methods: Between October 1964 and November 2000, 226 patients with 230 previously untreated primary invasive squamous cell carcinomas of the oral cavity were treated postoperatively with continuous-course external beam irradiation. All patients had a minimum follow-up of 2 years (analysis, November 2002).
T1-T2 glottic carcinomas may be treated with conservative surgery or radiotherapy. The goals of treatment are cure and laryngeal voice preservation. The aim of the current study was to review the pertinent literature and discuss the optimal management of early-stage laryngeal carcinoma.
View Article and Find Full Text PDFBackground: The purpose of this study was to analyze the results of radiotherapy (RT) alone or combined with surgery for adenoid cystic carcinoma.
Methods: Between September 1966 and November 2001, 101 previously untreated patients were treated with curative intent with RT alone or combined with surgery. Follow-up ranged from 0.