Publications by authors named "Vilde E Skingen"
Article Synopsis
- Cervical cancer is the fourth most common cancer in women globally, and this study introduces a deep learning framework to predict molecular subtypes in HPV-positive cervical squamous cell carcinoma using histology slides.
- The research analyzed three cohorts with 545 patients, demonstrating that the Digital-CMS scores can effectively predict both disease-specific and disease-free survival outcomes.
- Furthermore, the study found significant differences in the tumor microenvironment between subtypes, highlighting potential biomarkers and therapeutic targets that could guide clinical applications for better patient management.
Mechanisms regulating the gene expression program at different hypoxia severity levels in patient tumors are not understood. We aimed to determine microRNA (miRNA) regulation of this program at defined hypoxia levels from moderate to severe in prostate cancer. Biopsies from 95 patients were used, where 83 patients received the hypoxia marker pimonidazole before prostatectomy.
View Article and Find Full Text PDFPurpose: To evaluate the variability of the 18F-FDG-PET/CT-based metabolic tumor volume (MTV) in anal cancers during fractionated chemoradiotherapy (CRT), and assess the impact of this variability on dosimetric accuracy in MTV-targeted dose painting.
Methods: Eleven patients with anal squamous cell carcinoma who received fractionated chemoradiotherapy with curative intent were included. 18F-FDG PET/CT images were acquired at pre- and mid-treatment.
Background And Purpose: The biology behind individual hypoxia levels in patient tumors is poorly understood. Here, we used radiogenomics to identify associations between magnetic resonance imaging (MRI)-based hypoxia levels and biological processes derived from gene expression data in prostate cancer.
Materials And Methods: For 85 prostate cancer patients, MRI-based hypoxia images were constructed by combining diffusion-weighted images reflecting oxygen consumption and supply.
Article Synopsis
- HPV-associated cervical cancer is a major cause of cancer deaths in women, and this study analyzed 643 cases of cervical squamous cell carcinomas (CSCC) from the USA, Europe, and Sub-Saharan Africa.
- The researchers identified two distinct CSCC subtypes, C1 and C2, which have different prognoses, but the differences are not solely related to the HPV types (16 and 18) commonly found in these tumors.
- C2 tumors, accounting for about 20% of CSCCs, exhibit unique genomic changes and immune characteristics, leading to shorter survival rates, highlighting their significance for future treatment approaches.
Background: Gene signatures measured in a biopsy have been proposed as hypoxia biomarkers in prostate cancer. We assessed a previously developed signature, and aimed to determine its relationship to hypoxia and its heterogeneity within the dominant (index) lesion of prostate cancer.
Methods: The 32-gene signature was assessed from gene expression data of 141 biopsies from the index lesion of 94 patients treated with prostatectomy.
Many patients with locally advanced cervical cancer experience recurrence within the radiation field after chemoradiotherapy. Biomarkers of tumor radioresistance are required to identify patients in need of intensified treatment. Here, the biomarker potential of miR-200 family members was investigated in this disease.
View Article and Find Full Text PDFTumor hypoxia levels range from mild to severe and have different biological and therapeutical consequences but are not easily assessable in patients. Here we present a method based on diagnostic dynamic contrast enhanced (DCE) MRI that reflects a continuous range of hypoxia levels in patients with tumors of cervical cancer. Hypoxia images were generated using an established approach based on pixel-wise combination of DCE-MRI parameters and , representing oxygen consumption and supply, respectively.
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