Chromone derivatives suppress neuroinflammation and improve mitochondrial function in the sporadic form of Alzheimer's disease under experimental conditions.

Objectives: The study aims to estimate the neuroprotective effect of chromone derivatives in the sporadic form of Alzheimer's disease in the context of the relationship between changes in mitochondrial function and neuroinflammation.

Materials And Methods: Alzheimer's disease was modeled by injecting Aβ 1-42 fragments into the CA1 part of the hippocampus of animals. The test compounds and memantine were administered orally for 60 days from the moment the pathology was reproduced.

Chromon-3-aldehyde derivatives restore mitochondrial function in rat cerebral ischemia.

Objectives: This work aimed to assess the effect of 10 new chromon-3-aldehyde derivatives on changes of mitochondrial function under the conditions of brain ischemia in rats.

Materials And Methods: The work was executed on BALB/c male-mice (acute toxicity was evaluated) and male Wistar rats, which were used to model cerebral ischemia by permanent middle cerebral artery occlusion. The test-substances, 10 derivatives of chromon-3-aldehyde and the reference drug, N-acetylcysteine, were injected after modeling of ischemia for 3 days.