Publications by authors named "Viktoriia Makarova"
Aim: The peripheral tumor growth is accompanied by the accumulation of inflammatory mediators in the blood that can negatively influence blood-brain barrier function and neuronal structure and develop the cancer-associated depression. The aim of the study was to evaluate the neurobiological effects of lithium on hepatocellular carcinoma mice model.
Methods: In this study we analyzed the locomotor activity of lithium-treated tumor-bearing mice using the Phenomaster instrument.
Article Synopsis
- Tumor growth creates harmful changes in metabolism, damages tissues, and leads to the buildup of toxic substances in the bloodstream, particularly affecting the kidneys due to their delicate blood vessel structure.
- A study on mice with liver cancer indicated that the presence of the tumor and treatment with lithium carbonate resulted in increased levels of markers related to autophagy in kidney cells, suggesting enhanced cellular recycling processes.
- Observations showed that tumor growth caused structural changes in kidney cells, such as swelling of mitochondria and reduced organelle density, while lithium treatment improved the structure and density of key cellular components, potentially benefiting kidney function.