Publications by authors named "Viktoria Santner"
Patients with transthyretin amyloid cardiomyopathy (ATTR-CM) represent a high-risk heart failure population with continued unmet therapeutic needs. Sodium-glucose co-transporter 2 inhibitors (SGLT2i) improve cardiovascular outcomes in patients with heart failure across the whole spectrum of ejection fraction, and first evidence regarding their safety and effectiveness in patients with ATTR-CM is arising. This study investigates the association between SGLT2i therapy and clinical outcomes in these patients.
View Article and Find Full Text PDFBackground: Empagliflozin administered after acute myocardial infarction proofed to improve cardiometabolic parameters and biomarkers, but the impact on cardiac function is still largely unknown. The aim of this post-hoc echocardiographic sub-analysis of the EMMY trial was to provide in-depth echocardiographic analysis on the effects of empagliflozin versus placebo on standard and novel echocardiographic structural and functional parameters after acute myocardial infarction.
Methods: In this post-hoc analysis of the EMMY trial a subset of 313 patients (157 empagliflozin vs.
In patients with stable chronic heart failure with a reduced ejection fraction (HFrEF), left ventricular ejection fraction (LVEF) provides limited prognostic value, especially in patients with moderately to severely reduced LVEF. Echocardiographic parameters of right ventricular function may be associated with adverse clinical events in these patients. Therefore, we analyzed 164 patients with HFrEF in a prospective single-center cohort study to evaluate whether the parameters of right ventricular function are associated with worsening heart failure (WHF) hospitalizations, cardiovascular and all-cause deaths and combined endpoints.
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- Chronic heart failure (HFrEF) can lead to osteoporosis and vertebral fractures, increasing the risk of fractures and poor clinical outcomes.
- In this study of 205 outpatients with HFrEF, 15% had osteoporosis and 14% had vertebral fractures, with 27% showing either condition.
- Vertebral fractures were significantly linked to higher risks of cardiovascular death and worsening heart failure, while osteoporosis alone did not show a strong association with negative cardiovascular events.
Article Synopsis
- The study investigates the link between arterial hypertension (HTN) and markers of left ventricular dysfunction and inflammation in patients with hypertrophic cardiomyopathy (HCM).
- It compares 30 HCM patients with HTN to 30 without, assessing echocardiographic measures and inflammatory markers.
- Results reveal that while both groups had similar cardiac function, those with HTN showed higher levels of systemic inflammation, suggesting HTN's negative effects on HCM patients stem from overall body inflammation rather than direct heart function decline.
Pivotal outcome trials targeting heart failure with preserved (HFpEF) and mildly-reduced ejection fraction (HFmrEF) may have excluded patients at highest risk of poor outcomes. We aimed to assess eligibility for HFpEF/HFmrEF outcome trials in an unselected heart failure cohort and its association with all-cause mortality. Among 32.
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