Publications by authors named "Viktoria S Sharova"
Article Synopsis
- Postnatal exposure to bacterial endotoxin lipopolysaccharide (LPS) affects the activity of the hypothalamic-pituitary-gonadal (HPG) axis and alters gonadotropin-releasing hormone (GnRH) surges in rats, with long-term impacts on reproductive functions.
- Maternal exposure to LPS during pregnancy leads to delayed GnRH neuron migration and increased cytokine release, resulting in altered reproductive parameters in offspring.
- Key findings include reduced body weight and GnRH levels, delayed vaginal opening in females, and imbalanced plasma hormone levels, indicating that prenatal immune challenges can disrupt normal sexual development.
