FBN1 gene mutation characteristics and clinical features for the prediction of mitral valve disease progression.

Background: Until today, FBN1 gene mutation characteristics were not compared with clinical features for the prediction of mitral valve disease progression.

Methods: Therefore, we conducted a study of 116 patients (53 men, 63 women aged 33 ± 15 years) with a causative FBN1 gene mutation and ≤ moderate mitral valve regurgitation at baseline.

Results: During 7.