Publications by authors named "Viktoria Jehn"
Int J Mol Sci
October 2024
Article Synopsis
- PACAP is a neuropeptide known for its protective and anti-inflammatory effects, influencing both innate and adaptive immune responses, but there's limited research on its role in gut-associated lymphoid tissue.
- The study examined Peyer's patches in two groups of mice (wild-type and PACAP-deficient) at different ages, focusing on immune cell populations and checkpoint molecule expression.
- Findings revealed that aging affected T cell populations and checkpoint molecules in WT mice while PACAP KO mice showed altered immune responses, indicating that PACAP is critical for maintaining intestinal immune balance and may have implications for conditions like inflammatory bowel disease.
