Publications by authors named "Viktor Starenkiy"
Objective: The relevance of this study is conditioned by the need for urgent search and implementation of effective methods of treatment of urinary system diseases in people of different ages, as well as addressing issues of quality treatment of connective tissue diseases in general and its dysplasia in particular. The aim of the article is to identify congenital defects as visceral markers of connective tissue dysplasia.
Methods: The methodology of this study includes a survey of a group of children with considerable problems in the development and functioning of the urinary system at the age of 2 weeks to 3 years, in order to qualitatively select and determine the most effective methods of treatment.
External beam radiation therapy leads to cellular activation of the DNA damage response (DDR). DNA double-strand breaks (DSBs) activate the ATM/CHEK2/p53 pathway, inducing the transcription of stress genes. The dynamic nature of this transcriptional response has not been directly observed in vivo in humans.
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- Previous studies have explored how gene expression changes in blood can serve as biomarkers for radiation exposure, and this research specifically focused on FDXR transcriptional changes in humans exposed to different radiation procedures.
- Findings revealed that FDXR expression significantly increased 24 hours after most patients received radiotherapy and showed continuous elevation during treatment, with notable changes also observed after diagnostic CT scans.
- The study established a new method to measure radiation doses to blood based on exposure parameters, demonstrating a reliable dose-response relationship even at low radiation levels, indicating FDXR's potential for accurate in vivo dose estimation.