Incidence, risk factors and outcomes of cataract surgery after plaque brachytherapy for posterior uveal melanoma.

Purpose: To examine incidence, risk factors, and outcomes of cataract surgery after plaque brachytherapy for posterior uveal melanoma.

Design: Retrospective interventional cohort study contrasted with general population data.

Methods: All patients treated with plaque brachytherapy for a posterior uveal melanoma at Sweden's national referral center between 2010 and 2022 were included ( = 933).

Digital morphometry and cluster analysis identifies four types of melanocyte during uveal melanoma progression.

Background: Several types of benign and malignant uveal melanocytes have been described based on their histological appearance. However, their characteristics have not been quantified, and their distribution during progression from normal choroidal melanocytes to primary tumors and metastases has not been reported.

Methods: A total of 1,245,411 digitally scanned melanocytes from normal choroid, choroidal nevi, primary uveal melanomas, and liver metastases were entered into two-step cluster analyses to delineate cell types based on measured morphometric characteristics and expression of protein markers.

Multiorgan Involvement of Dormant Uveal Melanoma Micrometastases in Postmortem Tissue From Patients Without Coexisting Macrometastases.

Objectives: Almost half of all patients diagnosed with uveal melanoma will die of metastatic disease. This has been attributed to early seeding of micrometastases. We investigate the presence, density, organ involvement, and characteristics of micrometastases of uveal melanoma in tissue obtained at autopsy of patients with and without coexisting macrometastases.

Obesity paradox in uveal melanoma: high body mass index is associated with low metastatic risk.

Background: Metabolic factors and obesity may influence the development and progression of cancer. In this study, we examine their association with the risk of developing metastases of uveal melanoma.

Methods: Data on metabolic factors, medications, serum leptin levels, tumour leptin receptor RNA expression and clinical outcomes were examined in three cohorts.

A prognostic classification system for uveal melanoma based on a combination of patient age and sex, the American Joint Committee on Cancer and the Cancer Genome Atlas models.

Purpose: To revisit the independent importance of ciliary body involvement (CBI), monosomy 3 (M3), tumour size, histological and clinical factors in uveal melanoma (UM) and to devise a new prognostic classification based on a combination of the American Joint Committee on Cancer (AJCC) and the Cancer Genome Atlas (TCGA) models.

Methods: Two cohorts with a total of 1796 patients were included. Clinicopathological factors were compared between patients with and without CBI and M3.

Trends in Uveal Melanoma Presentation and Survival During Five Decades: A Nationwide Survey of 3898 Swedish Patients.

Background: In contrast to most other cancers, uveal melanoma (UM) is characterized by an absence of major improvements in patient survival during the last several decades. In this study, we examine changes in incidence rates, patient age and tumor size at diagnosis, treatment practices and survival for patients diagnosed in Sweden during the period 1960-2010.

Methods: All patients diagnosed with posterior UM between January 1st, 1960, and December 31st, 2009, in Sweden, were included ( = 3898).

The long-term prognosis of patients with untreated primary uveal melanoma: A systematic review and meta-analysis.

Purpose: To examine patient survival in untreated primary uveal melanoma.

Methods: Systematic review and meta-analysis.

Results: Seven studies with a total of 19 patients were included.

No differences in the long-term prognosis of iris and choroidal melanomas when adjusting for tumor thickness and diameter.

Objective: To assess the long-term prognosis for patients with iris melanomas and compare it with the prognosis for small choroidal melanomas.

Design: Retrospective observational case series.

Methods: All patients treated for iris melanomas at a single referral institution between January 1st 1986 and January 1st 2016 were included.

Vasculogenic mimicry correlates to presenting symptoms and mortality in uveal melanoma.

Purpose: Fluid-conducting extracellular matrix patterns known as vasculogenic mimicry (VM) have been associated with poor prognosis in uveal melanoma and other cancers. We investigate the correlations between VM, presenting symptoms, mortality, and the area density of periodic acid-Schiff positive histological patterns (PAS density).

Methods: Sixty-nine patients that underwent enucleation for uveal melanoma between 2000 and 2007 were included.