Publications by authors named "Viktor A Zouboulis"
Single-cell-based methods such as flow cytometry or single-cell mRNA sequencing (scRNA-seq) allow deep molecular and cellular profiling of immunological processes. Despite their high throughput, however, these measurements represent only a snapshot in time. Here, we explore how longitudinal single-cell-based datasets can be used for deterministic ordinary differential equation (ODE)-based modelling to mechanistically describe immune dynamics.
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- The S2k guideline for hidradenitis suppurativa/acne inversa (HS/AI) serves as a decision aid for selecting effective treatments for this chronic skin condition, which is characterized by painful lesions in areas rich in apocrine glands.
- The condition shows a prevalence of 0.3% in Germany, often diagnosed with a significant delay of about 10 years, and can severely impact a patient's quality of life due to the painful and recurrent nature of the disease.
- Treatment options include various medications like oral tetracyclines and biologics such as adalimumab, with a focus on assessing disease severity using tools like the International Hidradenitis Supp
Article Synopsis
- Chronic inflammation and issues with hair follicle cell differentiation are key factors in the development of hidradenitis suppurativa (HS), with obesity and metabolic syndrome also being significant risk factors.
- A systematic review examined the molecular mechanisms behind HS, identifying biomarkers and potential repurposing of existing drugs, including adalimumab, which is already approved for this condition.
- The study confirmed the interconnected nature of HS with other comorbidities like inflammatory bowel disease and arthritis, highlighting the importance of molecular research for better understanding and treatment of HS.
Background: Auricular keloids belong to the most perplexing medical conditions, which have significant psychosocial impact on the patient's body image and quality of life.
Summary: The article is purposed to provide dermatologists and plastic surgeons with the best proven practice using intralesional cryosurgery for the treatment of the different auricular keloid types in order to obtain superior clinical results by minimizing the probability of recurrence. In the past 20 years, the authors have developed novel procedures in order to increase the effectiveness of intralesional cryosurgery on auricular keloids, including hydrodissection, warm gauze technique, and excision of dangling skin.
Study Purpose: Effectiveness of cryotherapy on skin wart models.
Materials And Methods: Two small cryotherapy devices, Wartner and Wortie, were administered for 10″-60″ on tomatoes and potatoes used as skin wart models. Frozen surface and depth were evaluated by standardized photography and computer analysis.