Publications by authors named "Vikram Singh Shekhawat"
Article Synopsis
- Wolfram syndrome (WS) is a rare genetic disorder featuring a combination of symptoms like diabetes, optic atrophy, and hearing loss, primarily caused by a deficiency in arginine vasopressin.
- The case describes an early adolescent girl initially diagnosed with type 1 diabetes, who later presented with urinary issues and vision problems, leading to the discovery of optic atrophy and chronic kidney disease.
- Although she didn't exhibit all typical symptoms of WS, such as deafness, her case highlighted the need for thorough evaluation in juvenile diabetes patients, as early renal involvement could indicate conditions beyond common complications.
Impaired insulin sensitivity (IS) and β-cell dysfunction result in hyperglycaemia in patients of acromegaly. However, alterations in incretins and their impact on glucose-insulin homeostasis in these patients still remain elusive. Twenty patients of active acromegaly (10 each, with and without diabetes) underwent hyperinsulinemic euglycaemic clamp and mixed meal test, before and after surgery, to measure indices of IS, β-cell function, GIP, GLP-1 and glucagon response.
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