Characterizing thrombus adhesion strength on common cardiovascular device materials.

Thrombus formation in blood-contacting medical devices is a major concern in the medical device industry, limiting the clinical efficacy of these devices. Further, a locally formed clot within the device has the potential to detach from the surface, posing a risk of embolization. Clot embolization from blood-contacting cardiovascular devices can result in serious complications like acute ischemic stroke and myocardial infarction.

A hyper-viscoelastic uniaxial characterization of collagenous embolus analogs in acute ischemic stroke.

Purpose: Acute ischemic stroke is a leading cause of death and morbidity worldwide. Despite advances in medical technology, nearly 30% of strokes result in incomplete vessel recanalization. Recent studies have demonstrated that clot composition correlates with success rates of mechanical thrombectomy procedures.

Effect of left ventricular assist device on the hemodynamics of a patient-specific left heart.

This article describes the numerical efforts made to investigate the influence of a left ventricular assist device (LVAD) on the patient-specific left heart's hemodynamics. Two different computational geometries with left heart have been simulated over the entire cardiac cycle (case 1: healthy heart without LVAD and case 2: diseased heart with LVAD). The blood flow was simulated by implementing Bird-Carreau non-Newtonian model.

Comparative assessment of different versions of axial and centrifugal LVADs: A review.

Continuous-flow left ventricular assist devices (LVADs) have gained tremendous acceptance for the treatment of end-stage heart failure patients. Among different versions, axial flow and centrifugal flow LVADs have shown remarkable potential for clinical implants. It is also very crucial to know which device serves its purpose better to treat heart failure patients.

Simulation of Blood as Fluid: A Review From Rheological Aspects.

Blood flow in the human vascular system is a complex to understand example of fluid dynamics in a closed conduit. Any irregularities in the hemodynamics may lead to lethal cardiovascular disease like heart attack, heart failure and ischemia. Numerical simulation of hemodynamics in the blood vessel can facilitate a thorough understanding of blood flow and its interaction with the adjacent vessel wall.

Proposal of hemodynamically improved design of an axial flow blood pump for LVAD.

Left ventricular assist devices (LVAD) emerges as an effective clinical device providing life-saving support to heart patients. The design of blood pump of an LVAD involves incredible accuracy and thorough understanding of hemodynamics to mimic the functionality of a healthy ventricle. This work studies hemodynamics around an LVAD and proposes an improved model of axial blood pump for cardiac circulation without any hemolysis complications through numerical investigations.

Numerical simulation of centrifugal and hemodynamically levitated LVAD for performance improvement.

Left ventricular assist device (LVAD) provides an effective artificial support system to the heart patients. Despite the improved life survival rate, complications like hemolysis, blood trauma, and thrombus formation still limit the performance of the blood pump. The geometrical aspects of blood pumps majorly influence the hemodynamics, therefore these devices must be carefully engineered.