Scaling Relation between the Reduction Potential of Copper Catalysts and the Turnover Frequency for the Oxygen and Hydrogen Peroxide Reduction Reactions.

Changes in the electronic structure of copper complexes can have a remarkable impact on the catalytic rates, selectivity, and overpotential of electrocatalytic reactions. We have investigated the effect of the half-wave potential () of the Cu/Cu redox couples of four copper complexes with different pyridylalkylamine ligands. A linear relationship was found between of the catalysts and the logarithm of the maximum rate constant of the reduction of O and HO.

Ruthenium-Locked Helical Chirality: A Barrier of Inversion and Formation of an Asymmetric Macrocycle.

Upon coordination to metal centers, tetradentate ligands based on the 6,6'-bis(2″-aminopyridyl)-2,2'-bipyridine (bapbpy) structure form helical chiral complexes due to the steric clash between the terminal pyridines of the ligand. For octahedral ruthenium(II) complexes, the two additional axial ligands bound to the metal center, when different, generate diastereotopic aromatic protons that can be distinguished by NMR. Based on these geometrical features, the inversion barrier of helical [Ru(L)(RR'SO)Cl] complexes, where L is a sterically hindered bapbpy derivative and RR'SO is a chiral or achiral sulfoxide ligand, was studied by variable-temperature H NMR.

No effect of statin therapy on silent myocardial ischemia in patients with type 2 diabetes without manifest cardiovascular disease.

Objective: Coronary artery disease is the most important cause of mortality in patients with type 2 diabetes. We aimed to determine the prevalence of silent myocardial ischemia (SMI) and the effect of statin therapy on SMI in type 2 diabetic patients without manifest cardiovascular disease.

Research Design And Methods: A randomized, placebo-controlled, double-blind trial was performed in 250 patients with type 2 diabetes without manifest cardiovascular disease.

The effect of statin therapy on endothelial function in type 2 diabetes without manifest cardiovascular disease.

Objective: Cardiovascular disease (CVD) is the most important cause of mortality in patients with type 2 diabetes and is preceded by endothelial dysfunction. Flow-mediated dilation (FMD) is a noninvasive technique for measuring endothelial dysfunction. We aimed to determine the effect of long-term statin therapy versus placebo on FMD in patients with type 2 diabetes without manifest CVD.

Two-year statin therapy does not alter the progression of intima-media thickness in patients with type 2 diabetes without manifest cardiovascular disease.

Objective: Cardiovascular disease (CVD) is the most important cause of mortality in patients with type 2 diabetes. We aimed to determine the effect of statin therapy versus placebo on the progression of carotid intima-media thickness (IMT) in type 2 diabetic patients without manifest CVD.

Research Design And Methods: A randomized, placebo-controlled, double-blind clinical trial was performed in 250 patients with type 2 diabetes.

Impaired endothelium-dependent vasodilation in type 2 diabetes mellitus and the lack of effect of simvastatin.

Objective: Although type 2 diabetes is recognized as an independent risk factor for cardiovascular disease and cardiovascular disease is associated with endothelial dysfunction, the influence of type 2 diabetes per se on the endothelial function is controversial. HMG-CoA-reductase inhibitors have been shown to have short-term beneficial effects on endothelial dysfunction among patients with dyslipidemia or cardiovascular disease. The effect of HMG-CoA reductase inhibitors on the endothelial function in diabetes is largely unknown.

Monitoring renal function in obese patients with type 2 diabetes mellitus in daily practice.

Background: Endogenous creatinine clearance (GFR(24-hr)) and the Cockcroft formula (GFR(Cockcroft)) are used for the assessment of the glomerular filtration rate (GFR) in daily practice. The influence of extreme obesity in Type 2 diabetes mellitus (T2DM) on the Cockcroft formula was evaluated.

Methods: We compared GFR as calculated by GFR(Cockcroft) to GFR as determined by GFR(24-hr) in 210 patients with T2DM and normal serum creatinine levels.

Recurrence of hyperthyroidism in multinodular goiter after long-term drug therapy: a comparison with Graves' disease.

The chance of permanent remission after prolonged drug therapy was investigated in 41 patients with toxic multinodular goiter. For purposes of comparison a group of 41 patients with Graves' disease was also studied. After euthyroidism was achieved all patients received a combination of thionamide and thyroxine for at least 12 months.

Carbamyl phosphate synthetase-1 deficiency discovered after valproic acid-induced coma.

Valproic acid induced coma is presented in an adult patient without a history of metabolic disease. Liver biopsy revealed a reduction in activity of carbamyl phosphate synthetase-I, an enzyme obligated for transformation of ammonia to urea in the urea cycle. After recovery CT scan follow-up showed marked cerebral atrophy which did not exist prior to the state of coma.

A thyroglossal duct node as presenting symptom of Hashimoto's thyroiditis: a report of two cases.

Two patients with thyroglossal duct nodes are described. Both patients were suffering from autoimmune thyroiditis. The tumours resembling thyroglossal duct cysts presented as palpable nodes in the midline of the neck and moved upwards on swallowing.

Total body potassium in Bartter's syndrome before and during treatment with enalapril.

Total Body Potassium (TBK) was measured by whole body counting of 40K in 3 patients with Bartter's syndrome before, after 3 months and after 1 year of treatment with enalapril. In 2 patients TBK was found to be decreased before treatment, whereas TBK was within the normal range in the 3rd. During treatment serum potassium concentration and TBK increased in each subject and symptoms of fatigue and tetany disappeared.

Transient intrasellar collection of air during bromocriptine treatment of a prolactinoma.

A patient is described with a large prolactinoma with expansion into the sphenoid sinus. During bromocriptine treatment an intrasellar area of gas developed, continuous with the air in the sinus. No operation was performed, bromocriptine was continued.

Fertility of men with and without a varicocele.

The fertility of 742 men visiting our male infertility clinic was studied. A comparison was made between patients operated on for varicocele and patients treated in other ways. Of the men with a varicocele, 37.

Thyroid crisis presenting as coma.

Coma is a rare complication of thyrotoxicosis. A patient with coma due to a thyroid crisis is reported. The EEG showed extremely slow and low voltage activity, which gradually returned to normal.

CT in the diagnosis and follow-up of multiple abscesses in the liver.

Computed tomography (CT) in the diagnosis of liver abscesses is discussed. The accuracy of CT scan in differentiating hepatic masses is reviewed. Two CT control scans were performed during the follow-up period.

Double-blind cross over treatment with mesterolone and placebo of subfertile oligozoospermic men value of testicular biopsy.

Fifty-nine carefully selected oligozoospermic men were randomly treated with mesterolone (75 mg/day) or placebo to improve fertility. After 6 months the medication was changed from mesterolone to placebo or vice versa. Fourteen pregnancies occurred, 7 under mesterolone and 7 under placebo.