Publications by authors named "Vijitha K Senanayake"
Background: Biochemical changes associated with multiple sclerosis (MS), and its various clinical forms have not been characterized well. Therefore, we investigated the biochemistry of MS in relation to its natural history using targeted lipidomics platforms.
Methods: Cross-sectional serum samples from 24 secondary progressive (SPMS), 100 relapsing remitting (RRMS), 19 primary progressive MS (PPMS), and 55 age-matched control subjects were analyzed by flow injection tandem mass spectrometry for very long chain fatty acid (VLCFA) containing phosphatidyl ethanolamines (PtdEtn), plasmalogen ethanolamines (PlsEtn) and for novel anti-inflammatory gastrointestinal tract acids (GTAs).
Oleic acid consumption is considered cardio-protective according to studies conducted examining effects of the Mediterranean diet. However, animal models have shown that oleic acid consumption increases LDL particle cholesteryl oleate content which is associated with increased LDL-proteoglycan binding and atherosclerosis. The objective was to examine effects of varying oleic, linoleic and docosahexaenoic acid consumption on human LDL-proteoglycan binding in a non-random subset of the Canola Oil Multi-center Intervention Trial (COMIT) participants.
View Article and Find Full Text PDFBackground: It is well recognized that amounts of trans and saturated fats should be minimized in Western diets; however, considerable debate remains regarding optimal amounts of dietary n-9, n-6, and n-3 fatty acids.
Objective: The objective was to examine the effects of varying n-9, n-6, and longer-chain n-3 fatty acid composition on markers of coronary heart disease (CHD) risk.
Design: A randomized, double-blind, 5-period, crossover design was used.
Article Synopsis
- The Canola Oil Multicenter Intervention Trial (COMIT) aimed to study how different dietary oils affect cardiovascular disease risk factors in individuals with abdominal obesity, focusing on plasma fatty acid profiles.
- Conducted across three clinical sites in Canada and the US, COMIT included participants with specific health criteria, providing them with various oil-enriched diets over five 30-day phases, separated by washout periods.
- Preliminary results showed that out of 170 volunteers, 130 completed the study, and there was a notable increase of over 100% in plasma DHA levels during the DHA-enriched phase, indicating high dietary adherence.