Publications by authors named "Vijaykumar Shankar"
The objective of this study was to formulate aripiprazole (ARI)-loaded pH-modulated solid dispersions (SD) to enhance solubility, dissolution, and bioavailability via hot-melt extrusion (HME) technology. Kollidon® 12 PF (PVP) and succinic acid (SA) were selected after solubility screenings of various polymers and acidifiers. Several formulations, varying in screw speed and drug/polymer/acidifier ratios, were extruded using an 11 mm twin-screw extruder and were investigated for the effect of these variables.
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- Organoleptic agents are additives in pharmaceuticals and cosmetics that enhance coloring, flavoring, sweetening, and texturing, aiming to improve patient compliance and product appeal.
- These agents can be physically and chemically unstable, which may lead to degradation, especially when interacting with active pharmaceutical ingredients (APIs) or when exposed to light, air, pH changes, and temperature shifts.
- It's crucial to thoroughly review the physical and chemical properties of organoleptic agents to prevent potential issues with API stability and toxicity before their use in formulations.