Efficacy of Amniotic and Chorionic Membrane in Facial Wound Healing: A Comparative Study.

Background Advancements in regenerative techniques have been utilized in placental amnion and chorion for a variety of purposes. Their ability to regenerate tissues has led to their usage in tissue engineering, wound healing, and other therapeutic applications. This study aims to evaluate and compare the efficacy of amnion and chorion in facial tissue wound healing.

Unraveling Multicopper [Cu] and [Cu] Clusters with Rare μ-Sulfato and Linear μ-Oxido-Bridges as Potent Antibiofilm Agents against Multidrug-Resistant .

In this research article, two multicopper [Cu] and [Cu] clusters, [Cu(cpdp)(μ-SO)(Cl)(HO)]·3HO () and [Cu(cpdp)(μ-O)(Cl)(HO)]·2Cl () (Hcpdp = ,'-bis[2-carboxybenzomethyl]-,'-bis[2-pyridylmethyl]-1,3-diaminopropan-2-ol), have been explored as potent antibacterial and antibiofilm agents. Their molecular structures have been determined by a single-crystal X-ray diffraction study, and the compositions have been established by thermal and elemental analyses, including electrospray ionization mass spectrometry. Structural analysis shows that the metallic core of is composed of a trinuclear [Cu] assembly encapsulating a μSO group, whereas the structure of represents a hexanuclear [Cu] assembly in which two trinuclear [Cu] motifs are exclusively bridged by a linear μO group.

Ancillary-Ligand-Assisted Variation in Nuclearities Leading to the Formation of Di-, Tri-, and Tetranuclear Copper(II) Complexes with Multifaceted Carboxylate Coordination Chemistry.

The self-assembly of a carboxylate-based dinucleating ligand, ,'-bis[2-carboxybenzomethyl]-,'-bis[2-pyridylmethyl]-1,3-diaminopropan-2-ol (Hcpdp), and copper(II) ions in the presence of various exogenous ancillary ligands results in the formation of the new dinuclear complex [Cu(cpdp)(μ-Hisophth)]·2Hisophth·21HO (), trinuclear complex [Cu(Hcpdp)(Cl)] (), and tetranuclear complex [Cu(cpdp)(μ-Hphth)(μ-phth)(piconol)(Cl)]·3HO () (Hphth = phthalic acid; Hisophth = isophthalic acid; piconol = 2-pyridinemethanol; Cl = chloride). In methanol-water, the reaction of Hcpdp with CuCl·2HO at room temperature leads to the formation of . On the other hand, and have been obtained by carrying out the reaction of Hcpdp with CuCl·2HO/-CH(CONa) and CuCl·2HO/-CH(CONa)/piconol, respectively, in methanol-water in the presence of NaOH at ambient temperature.

A Family of [Zn] Complexes from the Carboxylate-Bridge-Supported Assembly of [Zn] Building Units: Synthetic, Structural, Spectroscopic, and Systematic Biological Studies.

The three discrete [Zn] complexes [NaZn(cpdp)(μ-Bz)(CHOH)][ZnCl][ZnCl(HO)]3CHOH1.5HO (), [NaZn(cpdp)(μ--OBz)(CHOH)]2HO (), and [NaZn(cpdp)(μ--NOBz)(CHOH)]Cl2HO (), supported by the carboxylate-based multidentate ligand ,'-bis[2-carboxybenzomethyl]-,'-bis[2-pyridylmethyl]-1,3-diaminopropan-2-ol (Hcpdp), have been successfully synthesized and fully characterized (Bz = benzoate; -OBz = dianion of -hydroxybenzoic acid; -NOBz = -nitrobenzoate). The complexes have been characterized by elemental analysis, FTIR, UV-vis, NMR spectroscopy, PXRD, and thermal analysis, including single-crystal X-ray crystallography of and .

5-(Diarylimino)- and 5-(sulfoximido)dibenzothiophenium triflates: syntheses and applications as electrophilic aminating reagents.

The one-pot synthesis of well-defined 5-(diarylimino) and 5-(sulfoximido)dibenzothiophenium triflates, respectively from diarylimines or sulfoximines, is reported and the structures of a series of these compounds are elucidated by X-ray crystallography. In analogy to their hypervalent I(iii) analogues, the iminoyl and sulfoximidoyl groups of these compounds can be selectively transferred to organic substrates. Specifically, the uncatalyzed imination of thiols or sulfinates proceeds with good yields, while under the mild reaction conditions offered by visible light photoredox catalysis, the radical amination of hydrazones or the sulfoximidation of benzylic, allylic and propargylic C-H bonds takes place satisfactorily.

Best Practices and Tools for Titrating Basal Insulins: Expert Opinion from an Indian Panel via the Modified Delphi Consensus Method.

Aim: To develop an evidence-based expert group consensus document on the best practices and simple tools for titrating basal insulins in persons with type 2 diabetes mellitus (T2DM).

Background: Glycemic control is suboptimal in a large proportion of persons with T2DM, despite insulin therapy, thereby increasing the risk of potentially severe complications. Early initiation of insulin therapy and appropriate dose titration are crucial to achieving glycemic targets.

Storing redox equivalent in the phenalenyl backbone towards catalytic multi-electron reduction.

Storing and transferring electrons for multi-electron reduction processes are considered to be the key steps in various important chemical and biological transformations. In this work, we accomplished multi-electron reduction of a carboxylic acid a hydrosilylation pathway where a redox-active phenalenyl backbone in Co(PLY-O,O)(THF), stores electrons and plays a preponderant role in the entire process. This reduction proceeds by single electron transfer (SET) from the mono-reduced ligand backbone leading to the cleavage of the Si-H bond.

A phenalenyl-based nickel catalyst for the hydroboration of olefins under ambient conditions.

In this report, nickel-catalyzed hydroboration of vinylarenes and aliphatic alkenes is investigated. The non-innocent phenalenyl ligand moiety in the nickel complex Ni(PLY)2(THF)2 (1) was utilized as an electron reservoir for the selective hydroboration reaction in the presence of pinacolborane under ambient conditions. The mechanistic investigations revealed that the alkene hydroboration reaction takes place through a single electron transfer (SET) from the phenalenyl ligand backbone leading to the cleavage of the B-H bond.

Transforming atmospheric CO into alternative fuels: a metal-free approach under ambient conditions.

This work demonstrates the first-ever completely metal-free approach to the capture of CO from air followed by reduction to methoxyborane (which produces methanol on hydrolysis) or sodium formate (which produces formic acid on hydrolysis) under ambient conditions. This was accomplished using an abnormal N-heterocyclic carbene (NHC)-borane adduct. The intermediate involved in CO capture (NHC-H, HCOO, B(OH)) was structurally characterized by single-crystal X-ray diffraction.

A safe and efficacious Pt(ii) anticancer prodrug: design, synthesis, in vitro efficacy, the role of carrier ligands and in vivo tumour growth inhibition.

Diaminocyclohexane-Pt(ii)-phenalenyl complexes (1 and 2) showed an appropriate balance between efficacy and toxicity. Compound 2 showed nearly two-fold higher tumour growth inhibition than oxaliplatin in a murine NSCLC tumour model, when a combined drug development approach was used. The fluorescent properties of phenalenone were utilized to understand the mechanistic details of the drug.

Phosphatase-like Activity of Tetranuclear Iron(III) and Zinc(II) Complexes.

Three new tetranuclear iron(III) and zinc(II) complexes, [Fe(cpdp)(phth)(OH)]·8HO (1), [Fe(cpdp)(terephth)(OH)] (2), and [Zn(Hcpdp)(suc)]Br·12HO (3), have been synthesized as models for the active site of phosphoester hydrolases by utilizing a polydentate ligand, N, N'-bis[2-carboxybenzomethyl]- N, N'-bis[2-pyridylmethyl]-1,3-diaminopropan-2-ol (Hcpdp) in combination with exogeneous phthalate (phth), terephthalate (terephth), and succinate (suc). Single crystal X-ray analyses reveal that the metallic core of complex 1 consists of four distorted octahedral iron(III) ions with average intraligand Fe---Fe separation of 3.656(2) Å, while the structure 3 represents a tetranuclear metallic core containing four distorted trigonal bipyramidal zinc(II) ions with average intraligand Zn---Zn separation of 3.

Tuning the redox non-innocence of a phenalenyl ligand toward efficient nickel-assisted catalytic hydrosilylation.

In this report, a ligand-redox assisted catalytic hydrosilylation has been investigated. A phenalenyl ligand coordinated nickel complex has been utilized as an electron reservoir to develop a base metal-assisted catalyst, which very efficiently hydrosilylates a wide variety of olefin substrates under ambient conditions. A mechanistic investigation revealed that a two-electron reduced phenalenyl based biradical nickel complex plays the key role in such catalysis.

Accessing Heterobiaryls through Transition-Metal-Free C-H Functionalization.

Herein we report a transition-metal-free synthetic protocol for heterobiaryls, one of the most important pharmacophores in the modern drug industry, employing a new multidonor phenalenyl (PLY)-based ligand. The current procedure offers a wide substrate scope (24 examples) with a low catalyst loading resulting in an excellent product yield (up to 95%). The reaction mechanism involves a single electron transfer (SET) from a phenalenyl-based radical to generate a reactive heteroaryl radical.

A new face of phenalenyl-based radicals in the transition metal-free C-H arylation of heteroarenes at room temperature: trapping the radical initiator C-C σ-bond formation.

The radical-mediated transition metal-free approach for the direct C-H bond functionalization of arenes is considered as a cost effective alternative to transition metal-based catalysis. An organic ligand-based radical plays a key role by generating an aryl radical which undergoes a subsequent functionalization process. The design principle of the present study takes advantage of a relatively stable odd alternant hydrocarbon-based phenalenyl (PLY) radical.

Highly Active Carbene Potassium Complexes for the Ring-Opening Polymerization of ε-Caprolactone.

Herein we report the synthesis of two complexes of potassium employing strongly nucleophilic carbenes, such as cyclic "(alkyl)(amino)carbene (cAAC) and abnormal N-heterocyclic carbene (aNHC). Both complexes are dimeric in the solid state and the two potassium centers are bridged by trimethylsilylamide. In these complexes, the carbene- - -K interaction is predominantly electrostatic in character, which has been probed thoroughly by NBO and AIM analyses.

ICT-Isomerization-Induced Turn-On Fluorescence Probe with a Large Emission Shift for Mercury Ion: Application in Combinational Molecular Logic.

A unique turn-on fluorescent device based on a ferrocene-aminonaphtholate derivative specific for Hg cation was developed. Upon binding with Hg ion, the probe shows a dramatic fluorescence enhancement (the fluorescence quantum yield increases 58-fold) along with a large red shift of 68 nm in the emission spectrum. The fluorescence enhancement with a red shift may be ascribed to the combinational effect of C═N isomerization and an extended intramolecular charge transfer (ICT) mechanism.

Inorganic Phosphate and Arsenate within New Tetranuclear Copper and Zinc Complexes: Syntheses, Crystal Structures, Magnetic, Electrochemical, and Thermal Studies.

Three, PO /HPO and AsO -incorporated, new tetranuclear complexes of copper(II) and zinc(II) ions have been synthesized and fully characterized. In methanol-water, reactions of Hcpdp (Hcpdp = ,'-Bis[2-carboxybenzomethyl]-,'-Bis[2-pyridylmethyl]-1,3-diaminopropan-2-ol) with copper(II) chloride in the presence of either NaOH/NaHPO·2HO or KOH/NaHAsO·7HO lead to the isolation of the tetranuclear complexes Na[Cu(cpdp)(μ-PO)](OH)·14HO () and K[Cu(cpdp)(μ-AsO)](OH)·16/HO (), respectively. Similarly, the reaction of Hcpdp with zinc(II) chloride in the presence of NaOH/NaHPO·2HO yields a tetranuclear complex, Na(HO)[Zn(cpdp)(μ-HPO)]Cl·12/HO ().

Osteomyelitis of Humerus and Intramuscular Abscess Due to Melioidosis.

Melioidosis is a clinically diverse disease caused by gram negative bacterium Burkholderia pseudomallei. It is a potential bioterrorism agent. The high risk group includes the agricultural and construction workers whose contact with contaminated soil and water may expose them to bacteria.

Metal-Free Reduction of CO to Methoxyborane under Ambient Conditions through Borondiformate Formation.

An abnormal N-heterocyclic carbene (aNHC) based homogeneous catalyst has been used for the reduction of carbon dioxide to methoxyborane in the presence of a range of hydroboranes under ambient conditions and resulted in the highest turnover number of 6000. A catalytically active reaction intermediate, [aNHC-H⋅9BBN(OCOH) ] was structurally characterized and authenticated by NMR spectroscopy. A detailed mechanistic cycle of this catalytic process via borondiformate formation has been proposed from tandem experimental and computational experiments.

An abnormal N-heterocyclic carbene based nickel complex for catalytic reduction of nitroarenes.

Herein we report the synthesis of a nickel(ii) dichloro complex bearing an abnormal N-heterocyclic carbene (aNHC). The NiCl2(aNHC)2 complex has been used as an efficient catalyst for the reduction of nitroarenes with hydrosilanes to give aromatic amines in good to excellent yields. This catalytic protocol can tolerate functional groups such as halides, alkenes or nitriles.

Switching closed-shell to open-shell phenalenyl: toward designing electroactive materials.

Open-shell phenalenyl chemistry started more than half a century back, and the first solid-state phenalenyl radical was realized only 15 years ago highlighting the synthetic challenges associated in stabilizing carbon-based radical chemistry, though it has great promise as building blocks for molecular electronics and multifunctional materials. Alternatively, stable closed-shell phenalenyl has tremendous potential as it can be utilized to create an in situ open-shell state by external spin injection. In the present study, we have designed a closed-shell phenalenyl-based iron(III) complex, Fe(III)(PLY)3 (PLY-H = 9-hydroxyphenalenone) displaying an excellent electrocatalytic property as cathode material for one compartment membraneless H2O2 fuel cell.

Design, synthesis and 3D-QSAR studies of new diphenylamine containing 1,2,4-triazoles as potential antitubercular agents.

A new series of new diphenylamine containing 1,2,4-triazoles were synthesized from 4-arylideneamino-5-[2-(2,6-dichlorophenylamino) benzyl]-2H-1,2,4-triazole-3(4H)-thiones 3a-f. The synthesized compounds were screened for in-vitro antimycobacterial and antibacterial activities. The synthesized compounds 4a, 4e and 4d have shown potential activity against Mycobacterium tuberculosis H37Rv strain with MIC of 0.

Clinical evaluation of sustained-release metronidazole gel versus metronidazole solution as an intracanal medicament in abscessed primary molars.

Aim: To evaluate the efficacy of metronidazole gel versus metronidazole solution against Enterococcus faecalis in abscessed primary molars.

Study Design: A clinical trial.

Method: Twenty pulpally involved non-vital carious human primary mandibular second molars with furcal abscess were randomly allocated into two groups to evaluate the efficacy of metronidazole gel (3% w/v) and metronidazole solution (0.