3,5-disubstituted pyridines with potent activity against drug-resistant clinical isolates.

We designed and synthesized a series of compounds with a 3,5-disubstituted pyridine moiety and evaluated them against (Mtb) and drug-resistant Mtb clinical isolates. A library of 3,5-disubstituted pyridine was synthesized. The compounds were screened for activity against H37Rv.

Novel 1,3,4-oxadiazoles as antitubercular agents with limited activity against drug-resistant tuberculosis.

Aim: In recent times, heterocyclic chemotypes are being explored for the development of new antimycobacterials that target the drug-resistant tuberculosis. Here, we are disclosing the 5-substitued 2-mercapto-1,3,4-oxadiazoles as potent antitubercular agents.

Methodology: A small library of 2-mercapto-1,3,4-oxadiazoles was synthesized using various acids.