Publications by authors named "Vijayakumari Mahadevan Hari Priya"
Phosphodiesterase-5 (PDE5) is a homodimeric enzyme that specifically targets cyclic guanosine monophosphate (cGMP), that mediates many downstream effects such as vasodilation, neurotransmission, and calcium homeostasis. Considering the functions of cGMP, inhibition of PDE5 has been established to have several therapeutic effects in disease conditions such as cancer, cardiovascular diseases and Alzheimer's disease. Consequently, many PDE5 inhibitors were developed but with severe adverse effects such as non-arteritic anterior ischemic optic neuropathy (NAION), priapism, etc.
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- Erectile dysfunction (ED) is a complex sexual disorder influenced by physical, relational, and psychological factors, often leading to health issues like depression and anxiety due to its impact on sexual performance.
- Traditional treatment methods, including lifestyle changes and medications, have limitations in safety and effectiveness, prompting interest in new methods, such as nanomedicine, for managing ED.
- Nanotechnology offers advanced drug delivery systems that improve treatment outcomes by ensuring targeted delivery and minimizing side effects, making it a promising area for future clinical applications in ED management.