A Highly Selective Schiff Base Based Chemodosimeter for the Detection of Perfluorooctanoic Acid by Optical Biosensor.

A simple imine derivative based sensor (IDP) has been synthesized and characterized by  H NMR,  C NMR and mass spectral techniques. IDP is more capable of detecting perfluorooctanoic acid (PFOA) in a selective and sensitive manner. The PFOA as a biomarker interacts with IDP and shows "TURN-ON" response by colorimetric and fluorimetric method.

Highly Sensitive and Selective Detection of Melatonin in Biofluids by Antipyrine Based Fluorophore.

A simple fluorescent based organic fluorophore was synthesized and it shows significant fluorescent intensity with melatonin (MLN). Hence, it was applicable to the detection of MLN by colorimetric and fluorimetric techniques at neutral pH. Under optimized experimental condition, the synthesized organic fluorophore detects MLN selectively in the presence of other interfering biomolecules through ICT mechanism.

Effective Detection of Phenylalanine Using Pyridine Based Sensor.

Pyridine based organic molecule as probe has been synthesized for the detection of phenylalanine (PA) biomarker. The synthesized probe is characterized by H and C NMR and mass spectroscopic studies. The photophysical properties for the probe has recorded by colorimetric and fluorimetric techniques.

Development of Optical Biosensor for the Detection of Glutamine in Human Biofluids Using Merocyanine Dye.

Merocyanine dye based fluorescent organic compound has been synthesized for the detection of glutamine. The probe showed remarkable fluorescent intensity with glutamine through ICT (Intermolecular Charge Transfer Mechanism). Hence, it is tested for the detection of glutamine using colorimetric and fluorimetric techniques in physiological and neutral pH (7.

Implementation of a Quality Improvement Initiative to Decrease Opioid Prescribing in General Surgery.

Background: There is increasing need to avoid excess opioid prescribing after surgery. We prospectively assessed overprescription in our hospital system and used these data to design a quality improvement intervention to reduce overprescription.

Materials And Methods: Beginning in January 2017, an e-mail-based survey to assess the quantity of opioids used postoperatively as well as patient-reported pain control was sent to all surgical patients in a 23-hospital system.

Acute noncontrast T1-weighted magnetic resonance imaging predicts chronic radiofrequency ablation lesions.

Background: Magnetic resonance imaging (MRI) has been used to visualize radiofrequency (RF) ablation lesions but the relationship between volumes that enhance in acute MRI and the chronic lesion size is unknown.

Objectives: The main goal was to use noncontrast (native) T1-weighted (T1w) MRI and late gadolinium enhancement (LGE)-MRI to visualize lesions acutely and chronically and correlate the acute area of enhancement with chronic lesion size in histology.

Materials And Methods: In a canine (n = 9) model RF ablation lesions were created in both ventricles.

Surgeon and hospital cost variability for septoplasty and inferior turbinate reduction.

Background: Septoplasty and turbinate reduction (STR) is a common procedure for which cost reduction efforts may improve value. The purpose of this study was to identify sources of variation in medical facility and surgeon costs associated with STR, and whether these costs correlated with short-term complications.

Methods: An observational cohort study was performed in a multifacility network using a standardized cost-accounting system to determine costs associated with adult STR from January 1, 2008 to July 31, 2015.

Surgical stabilization of severe rib fractures decreases incidence of retained hemothorax and empyema.

Background: Retained hemothorax (RH) is relatively common after chest trauma and can lead to empyema. We hypothesized that patients who have surgical fixation of rib fractures (SSRF) have less RH and empyema than those who have medical management of rib fractures (MMRF).

Methods: Admitted rib fracture patients from January 2009 to June 2013 were identified.

Post-contrast myocardial T(1) and ECV disagree in a longitudinal canine study.

Both post-contrast myocardial T1 and extracellular volume (ECV) measurements have been associated with diffuse interstitial fibrosis. The cardiovascular magnetic resonance (CMR) field is migrating towards ECV, because it is largely insensitive to confounders that affect post-contrast myocardial T1 . Despite the theoretical advantages of myocardial ECV over post-contrast myocardial T1 , systematic experimental studies comparing the two measurements are largely lacking.

Arrhythmia insensitive rapid cardiac T1 mapping pulse sequence.

Purpose: To develop an arrhythmia-insensitive rapid (AIR) cardiac T1 mapping pulse sequence for quantification of diffuse fibrosis.

Methods: An arrhythmia-insensitive cardiac T1 mapping pulse sequence was developed based on saturation recovery T1 weighting, which is inherently insensitive to heart rate and rhythm, and two single-shot balanced steady-state free precession image acquisitions with centric k-space ordering, where T1 calculation is inherently insensitive to T2 effects. Its performance against conventional cardiac T1 mapping based on inversion recovery (i.

Identification and acute targeting of gaps in atrial ablation lesion sets using a real-time magnetic resonance imaging system.

Background: Radiofrequency ablation is routinely used to treat cardiac arrhythmias, but gaps remain in ablation lesion sets because there is no direct visualization of ablation-related changes. In this study, we acutely identify and target gaps using a real-time magnetic resonance imaging (RT-MRI) system, leading to a complete and transmural ablation in the atrium.

Methods And Results: A swine model was used for these studies (n=12).

Dark regions of no-reflow on late gadolinium enhancement magnetic resonance imaging result in scar formation after atrial fibrillation ablation.

Objectives: The aim of this study was to assess acute ablation injuries seen on late gadolinium enhancement (LGE) magnetic resonance imaging (MRI) immediately post-ablation (IPA) and the association with permanent scar 3 months post-ablation (3moPA).

Background: Success rates for atrial fibrillation catheter ablation vary significantly, in part because of limited information about the location, extent, and permanence of ablation injury at the time of procedure. Although the amount of scar on LGE MRI months after ablation correlates with procedure outcomes, early imaging predictors of scar remain elusive.

Real-time magnetic resonance imaging-guided radiofrequency atrial ablation and visualization of lesion formation at 3 Tesla.

Background: Magnetic resonance imaging (MRI) allows visualization of location and extent of radiofrequency (RF) ablation lesion, myocardial scar formation, and real-time (RT) assessment of lesion formation. In this study, we report a novel 3-Tesla RT -RI based porcine RF ablation model and visualization of lesion formation in the atrium during RF energy delivery.

Objective: The purpose of this study was to develop a 3-Tesla RT MRI-based catheter ablation and lesion visualization system.

Left atrial strain and strain rate in patients with paroxysmal and persistent atrial fibrillation: relationship to left atrial structural remodeling detected by delayed-enhancement MRI.

Background: Atrial fibrillation (AF) is a progressive condition that begins with hemodynamic and/or structural changes in the left atrium (LA) and evolves through paroxysmal and persistent stages. Because of limitations with current noninvasive imaging techniques, the relationship between LA structure and function is not well understood.

Methods And Results: Sixty-five patients (age, 61.

Magnetic resonance imaging-confirmed ablative debulking of the left atrial posterior wall and septum for treatment of persistent atrial fibrillation: rationale and initial experience.

Introduction: Though pulmonary vein (PV) isolation has been widely adopted for treatment of atrial fibrillation (AF), recurrence rates remain unacceptably high with persistent and longstanding AF. As evidence emerges for non-PV substrate changes in the pathogenesis of AF, more extensive ablation strategies need further study.

Methods: We modified our PV antrum isolation procedure to include abatement of posterior and septal wall potentials.

Temporal left atrial lesion formation after ablation of atrial fibrillation.

Background: Atrial fibrillation (AF) ablation uses radiofrequency (RF) energy to induce thermal damage to the left atrium (LA) in an attempt to isolate AF circuits. This injury can be seen using delayed enhancement magnetic resonance imaging (DE-MRI).

Objective: The purpose of this study was to describe DE-MRI findings of the LA in the acute and chronic stages postablation.

High-pass GRAPPA: an image support reduction technique for improved partially parallel imaging.

Partially parallel imaging (PPI) is a widely used technique in clinical applications. A limitation of this technique is the strong noise and artifact in the reconstructed images when high reduction factors are used. This work aims to increase the clinical applicability of PPI by improving its performance at high reduction factors.

Reconstruction in image space using basis functions for partially parallel imaging.

General theory of a new reconstruction technique for partially parallel imaging (PPI) is presented in this study. Reconstruction in Image space using Basis functions (RIB) is based on the general principle that the PPI reconstruction in image space can be represented by a pixel-wise weighted summation of the aliased images directly from undersampled data. By assuming that these weighting coefficients for unaliasing can be approximated from the linear combination of a few predefined basis functions, RIB is capable of reconstructing the image within an arbitrary region.

A software channel compression technique for faster reconstruction with many channels.

In magnetic resonance imaging, highly parallel imaging using coil arrays with a large number of elements is an area of growing interest. With increasing channel numbers for parallel acquisition, the increased reconstruction time and extensive computer memory requirements have become significant concerns. In this work, principal component analysis (PCA) is used to develop a channel compression technique.

Self-calibration method for radial GRAPPA/k-t GRAPPA.

Generalized autocalibrating partially parallel acquisitions (GRAPPA), an important parallel imaging technique, can be easily applied to radial k-space data by segmenting the k-space. The previously reported radial GRAPPA method requires extra calibration data to determine the relative shift operators. In this work it is shown that pseudo-full k-space data can be generated from the partially acquired radial data by filtering in image space followed by inverse gridding.

Gradient weighted smoothing for MRI intensity correction.

In magnetic resonance imaging (MRI), surface coils have the advantage of higher signal to noise ratio (SNR) but suffer from image inhomogeneity due to the non-uniform sensitivity profile. To remove bright spots caused by non-uniform sensitivity profiles, a gradient weighted smoothing method is discussed in this work. A partial differential equations (PDE) based model is applied for this locally adaptive smoothing.

Improved partial k-space reconstruction technique for dynamic myocardial perfusion MRI.

The advent of partially parallel k-space data acquisition and reconstruction techniques has resulted in a drastic reduction in acquisition time. In this work, we have shown that the use of a new hybrid technique for reconstruction of partial k-space data can reduce acquisition time without loss of spatiotemporal resolution. The technique is termed hybrid k-t GRAPPA since it is a combination of k-t GRAPPA and an image-k-space keyhole technique.

Software Compression for Partially Parallel Imaging with Multi-channels.

In magnetic resonance imaging, multi-channel phased array coils enjoy a high signal to noise ratio (SNR) and better parallel imaging performance. But with the increase in number of channels, the reconstruction time and requirement for computer memory become inevitable problems. In this work, principle component analysis is applied to reduce the size of data and protect the performance of parallel imaging.