Publications by authors named "Vijaya B"

Ammonia (NH) vapour is considered as a hazardous volatile, which has the potential to cause health concerns in humans. Exposure to NH can lead to potentially fatal, severe burn injuries to human eyes, can cause encephalopathy, and also affects various physiological systems, including the liver, the kidneys and the immune system. Due to these prime factors, the advancement of chemi-resistive ammonia gas sensors at room temperature has drawn considerable attention among researchers.

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Polymers have been integral to the advancement of biomedicine, owing to their exceptional versatility and functionality. Among these, polyvinyl alcohol (PVA) and chitosan both natural polymers stand out for their remarkable biocompatibility, biodegradability, and unique properties. This review article provides a comprehensive examination of the diverse applications of PVA and chitosan in three pivotal areas: tissue engineering, drug delivery, and biosensors.

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Nonsteroidal anti-inflammatory drugs are widely utilised to alleviate pain and reduce inflammation in both human and veterinary medicine. Despite their therapeutic benefits, NSAIDs pose environmental concerns due to their possible ecotoxicity. NSAIDs can enter aquatic ecosystems through wastewater discharge as it is very difficult to extract NSAIDs by conventional wastewater treatment, thus affecting aquatic life.

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Cervical cancer is one of the most malignant reproductive diseases seen in women worldwide. The identification of dysregulated genes in clinical samples of cervical cancer may pave the way for development of better prognostic markers and therapeutic targets. To identify the dysregulated genes (DEGs), we have retrospectively collected 10 biopsies, seven from cervical cancer patients and three from normal subjects who underwent a hysterectomy.

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Article Synopsis
  • Chronic lymphedema can lead to serious complications, including the development of skin cancers like cutaneous lymphomas.
  • A specific case of primary cutaneous diffuse large B-cell lymphoma in a patient with lower limb lymphedema is discussed, alongside a review of 12 similar cases.
  • The condition may impair the local immune response, increasing the risk of skin cancer formation.
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Background: Innovation in the treatment of lower extremity lymphedema has received low priority from the governments and pharmaceutical industry. Advancing lymphedema is irreversible and initiates fibrosis in the dermis, reactive changes in the epidermis and subcutis. Most medical treatments offered for lymphedema are either too demanding with a less than satisfactory response or patients have low concordance due to complex schedules.

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A 50-year-old man presented with slow-growing dry, rough, micaceous scaly plaque over glans penis, which was compatible with clinical diagnosis of pseudoepitheliomatous keratotic and micaceous balanitis (PKMB) and histologically suggestive of PKMB without cellular atypia. He was treated successfully with topical 5-fluorouracil with complete clearance of lesion in 3 weeks without recurrence for 10 months. PKMB is an extremely rare and interesting condition; only a handful cases have been reported in world literature.

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Background: Primary localized cutaneous amyloidosis (PCA) is a relatively rare condition characterized by amyloid deposition in dermis without systemic involvement. Although, histopathological examination of the lesion reveals amorphous eosinophilic deposits in papillary dermis examination of congo red stained slides under polarized light will give definitive diagnosis

Aims: To study the clinicopathological features of cutaneous amyloidosis emphasizing the utility of polarized light in diagnosis.

Materials And Methods: A clinicopathological study of primary cutaneous amyloidosis over a period of 8 years was undertaken.

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Acral cutaneous metastasis is a rare phenomenon. A 38-year-old woman presented with painful lesions in the left hand since 1 month. On examination, multiple painful, erythematous, lobulated plaques and nodules were present over the palmar aspect of the finger tips and thenar eminence.

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Subcutaneous panniculitic-like T-cell lymphoma constitutes a distinctive clinicopathologic entity derived from cytotoxic T lymphocytes. A 25-year-old female presented with fever and skin lesions over the upper limb, lower limb and trunk since 2 years. On examination, there were multiple subcutaneous, tender, erythematous, poorly circumscribed indurated plaques and nodules on the upper limbs and lower limbs.

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Lymphocutaneous sporotrichosis is unusual in southern India. The diagnosis was made by histopathological examination which is purported to have poor sensitivity. The culture of the specimen confirmed the diagnosis.

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Wistar is the oldest rat strain to be introduced in biomedical research, and various stocks of this strain are maintained in laboratories across the globe. The Wistar strain maintained in our facilities is 85 years old and is not typed genetically so far. Recently, two obese mutant rat strains evolved from this stock, one with euglycemia and the other with impaired glucose tolerance.

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Polyacrylamide (pAAm) particles crosslinked with N,N-methylenebis-acrylamide/ethylene glycol dimethacrylate (NNMBA/EGDMA) have been prepared in water-methanol medium by the dispersion polymerization using poly(vinyl pyrrolidone), PVP as a steric stabilizer. 5-fluorouracil an anticancer drug, has been loaded in situ into the crosslinked pAAm particles. Plain as well as drug loaded microparticles have been characterized by differential scanning calorimetry (DSC) and X-ray diffraction studies (XRD) and scanning electron microscopy (SEM).

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