Publications by authors named "Vijay Simha"
Background: Neoadjuvant chemotherapy (NACT) with TPF (docetaxel, cisplatin, and 5FU) is one of the treatment options in very locally advanced oral cancer with a survival advantage over PF (cisplatin and 5FU). TP (docetaxel and cisplatin) has shown promising results with a lower rate of adverse events but has never been compared to TPF.
Methods: In this phase 3 randomized superiority study, adult patients with borderline resectable locally advanced oral cancers were randomized in a 1:1 fashion to either TP or TPF.
Introduction: Oxaliplatin is a platinum containing alkylating agent commonly used in the management of colorectal cancers. The most common dose-limiting toxicity of oxaliplatin is peripheral neuropathy, which can be severe enough to cause treatment discontinuation. We present a case of dysarthria and laryngopharyngeal dysesthesia (LPD) that developed during the first dose of oxaliplatin, which showed dose-dependent reduction in severity in subsequent cycles.
View Article and Find Full Text PDFBackground: Pregnancy associated breast cancer (PABC) is a rare entity and defined as breast cancer diagnosed during pregnancy or one-year post-partum. There is sparse data especially from low and middle-income countries (LMIC) and merits exploration.
Methods: The study (2013-2020) evaluated demographics, treatment patterns and outcomes of PABC.
Highly Specific Culture-Independent Detection of YGNGV Motif-Containing Pediocin-Producing Strains.
Probiotics Antimicrob Proteins
March 2013
Article Synopsis
- A novel method combines initial microbiological screening with highly specific PCR to identify strains that produce YGNGV motif-containing pediocin.
- Spot on the lawn assays help select strains that are acid-free, hydrogen peroxide-free, and secrete heat-stable inhibitory substances, followed by PCR to amplify specific gene fragments.
- The method successfully identified three new strains (P. pentosaceus NCDC35, E. faecium NCDC124, and Lactobacillus plantarum NCDC20) that express the desired pediocins, confirmed through various validation techniques like restriction enzyme digestion and nucleotide sequencing.
The use of pediocins as food additives or drugs requires a simple and rapid method by which large quantities of homogeneous pediocin are produced at industrial level. Two centrifugation steps required during initial stages of purification i.e.
View Article and Find Full Text PDFObjective: To study the circulation pattern of respiratory viruses in out patients department (OPD) and hospitalized children with acute respiratory tract infection.
Methods: Nasopharyngeal aspirates were collected from 385 children with acute respiratory tract infections attending the OPD (n=199, 51.7%) and admitted to pediatric ward (n=186, 43.