Publications by authors named "Vijay Kumar Sagar"
Article Synopsis
- Alterations in NADH and NADPH metabolism are linked to aging, cancer, and Alzheimer's Disease.
- Research shows that tau oligomers increase mitochondrial NADPH production through an enzyme called NADK2 in both human neurons and mouse brains.
- This increase in NADPH contributes to a harmful cycle that enhances the internalization of tau oligomers, leading to increased toxicity in neurons.
Introduction: Reduced brain energy metabolism, mammalian target of rapamycin (mTOR) dysregulation, and extracellular amyloid beta (Aβ) oligomer (xcAβO) buildup are some well-known Alzheimer's disease (AD) features; how they promote neurodegeneration is poorly understood. We previously reported that xcAβOs inhibit nutrient-induced mitochondrial activity (NiMA) in cultured neurons. We now report NiMA disruption in vivo.
View Article and Find Full Text PDFIntroduction: Reduced brain energy metabolism, mTOR dysregulation, and extracellular amyloid-β oligomer (xcAβO) buildup characterize AD; how they collectively promote neurodegeneration is poorly understood. We previously reported that xcAβOs inhibit N utrient-induced M itochondrial A ctivity (NiMA) in cultured neurons. We now report NiMA disruption .
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