Publications by authors named "Vijay Kumar P"
Article Synopsis
- The study examines the fertility potential of immature testicular tissue (ITT) in pre-pubertal boys with cancer, focusing on spermatogonial and Sertoli cell populations.
- Researchers retrieved ITT from 14 boys (7 with haematological malignancies and 7 with non-haematological cancers) and conducted histopathological and immunochemical analyses.
- Findings showed no significant difference in the number of spermatogonia between the two cancer types, contributing valuable data to the field of pediatric male oncofertility.
Article Synopsis
- The clinical genomics knowledgebase is constantly evolving, which poses challenges for clinical labs due to limited resources for reassessing genetic variants.
- In a study, automated notifications were sent to clinical sites when variants were reclassified, leading to a summary of the reclassifications and a framework to identify variants likely to change status.
- Out of 1855 variants reanalyzed, 2% were reclassified, impacting 0.6% of participants, with significant changes mostly due to new evidence, underscoring the necessity of regular updates and automated systems in clinical genetics.
Background And Objectives: Rh is one of the most diverse and complex blood group systems. Recently, next generation sequencing (NGS) has proven to be a viable option for RH genotyping. We have developed automated software (bloodTyper) for determining alleles encoding RBC antigens from NGS-based whole genome sequencing (WGS).
View Article and Find Full Text PDFBackground: The MNS blood group system is defined by three homologous genes: GYPA, GYPB, and GYPE. GYPB encodes for glycophorin B (GPB) carrying S/s and the "universal" antigen U. RBCs of approximately 1% of individuals of African ancestry are U- due to absence of GPB.
View Article and Find Full Text PDFAn efficient protocol for the introduction of acetoxy and hydroxy functionalities on unactivated aryl sp2 carbons of oxobenzoxazine derivatives via an ortho-C-H activation reaction using a palladium catalyst has been developed for the first time. Interestingly, this intermolecular C-H functionalization reaction takes place in a facile and simple manner with high chemo- and site selectivity.
View Article and Find Full Text PDFForskolin C-isoxazole derivatives (3,5-regioisomers) (11a-e, 14, 15a-h and 15, 16a-g) were synthesized regioselectively by adopting 1,3-dipolar cycloadditions. These derivatives were tested using estrogen receptor positive breast cancer cell lines MCF-7 and BT-474. Majority of the compounds exhibited activity against the p53-positive MCF-7 breast cancer cells but not against the p53-negative BT-474 breast cancer cells.
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