Publications by authors named "Vijay Induvadan Kulkarni"
Article Synopsis
- A transformation towards continuous manufacturing (CM) and automated model-based control is being considered to meet market demands and regulatory standards in solid dosage forms, offering advantages over traditional batch manufacturing.
- Continuous manufacturing integrates various processes while maintaining quality through process analytical technology (PAT), with the twin screw extruder (TSE) being a notable substitute for batch granulation in the pharmaceutical industry.
- The article discusses various granulation techniques utilizing TSE, its components and integration with PAT tools, and the future potential of TSE in nutraceuticals and nanotechnology, highlighting its ability to work alongside computational studies for improved efficiency.
In this study, drug-cyclodextrin (CD) complexes were prepared using hot liquid extrusion (HLE) process with an aim to improve solubility and bioavailability of carbamazepine. Saturation solubility studies of CBZ in water and different pH media showed a pH-independent solubility. Phase solubility studies of CBZ at different molar concentrations of beta-cyclodextrin (β-CD) and hydroxypropyl beta-cyclodextrin (HP-β-CD) indicated A-type solubility profile with stability constants of 574 M and 899 M for β-CD and HP-β-CD.
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