Publications by authors named "Viiklepp K"
Cutaneous squamous cell carcinoma (cSCC) is the most common metastatic skin cancer. The incidence of cSCC is increasing globally and the prognosis of metastatic disease is poor. Currently there are no specific targeted therapies for advanced or metastatic cSCC.
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- Cutaneous squamous cell carcinoma (cSCC) is the most common type of skin cancer that can spread to other parts of the body, and it shows a link between complement components and cancer growth.* -
- Research found that factor D (FD), an enzyme in the alternative complement pathway, is significantly more active and produced in cSCC cells compared to normal skin cells, indicating its role in cSCC development.* -
- The study highlights FD as a potential new biomarker and target for therapy, showing that blocking FD can reduce cSCC cell growth by affecting key signaling pathways.*
Cutaneous squamous cell carcinoma (cSCC) is the most common metastatic skin cancer, with increasing incidence worldwide. Previous studies have shown the role of the complement system in cSCC progression. In this study, we have investigated the mechanistic role of serine proteinase C1r, a component of the classical pathway of the complement system, in cSCC.
View Article and Find Full Text PDFEpidermal keratinocyte-derived cutaneous squamous cell carcinoma (cSCC) is the most common metastatic skin cancer with high mortality rates in the advanced stage. Chronic inflammation is a recognized risk factor for cSCC progression and the complement system, as a part of innate immunity, belongs to the microenvironment of tumors. The complement system is a double-edged sword in cancer, since complement activation is involved in anti-tumor cytotoxicity and immune responses, but it also promotes cancer progression directly and indirectly.
View Article and Find Full Text PDFBackground: The incidence of epidermal keratinocyte-derived cutaneous squamous cell carcinoma (cSCC) is increasing worldwide.
Objectives: To study the role of the complement classical pathway components C1q, C1r and C1s in the progression of cSCC.
Methods: The mRNA levels of C1Q subunits and C1R and C1S in cSCC cell lines, normal human epidermal keratinocytes, cSCC tumours in vivo and normal skin were analysed with quantitative real-time polymerase chain reaction.