Publications by authors named "Vignesh Venkatasubramanian"
RSC Med Chem
October 2024
Article Synopsis
- The rise of antimicrobial-resistant strains is a major threat to existing treatments, highlighting the need for new therapies.
- Researchers developed a new compound, QPyNATh, by modifying thiazolidine with fatty acids to enhance its ability to disrupt bacterial membranes, showing effective inhibition against Gram-positive bacteria while being selective for bacterial cells over human cells.
- Animal studies demonstrated that QPyN16Th significantly reduced MRSA infections in zebrafish and showed no signs of resistance developing, suggesting its potential as a biocompatible treatment for resistant bacterial infections.
