Publications by authors named "Vignesh Thiagarajan"

In many rapidly urbanizing and industrializing countries, atmospheric pollution causes severe environmental problems and compromises the health of humans and ecosystems. Atmospheric emissions, which encompass gases and particulate matter, can be transported back to the earth's surface through atmospheric deposition. Atmospheric deposition supplies chemical species that can serve as nutrients and/or toxins to aquatic ecosystems, resulting in wide-ranging responses of aquatic organisms.

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The increased usage of titanium dioxide nanoparticles (nTiO) in consumer products has led to their prevalence in freshwater systems. Nanoplastics, a secondary pollutant, can significantly influence the toxic effects of nTiO in freshwater organisms. The present study investigates the role of fluorescent nanoplastics (FNPs) in modifying the harmful effects of P25 nTiO in freshwater algae Scenedesmus obliquus.

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Increasing usage of both nanomaterials and pharmaceuticals and their unabated release to the marine ecosystem pose a serious concern nowadays. The toxicity of the mixture of TiO NPs and tetracycline (TC) in the marine species are not very well covered in prior literature. The current study explores the joint toxic effects of TiO NPs and TC in a simulated marine food chain: Chlorella sp.

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The rising use of contaminants such as nanoparticles and microplastics has taken a heavy toll on the marine environment. However, their combined toxic effects on the species across various trophic levels remain quite unexplored. The aim of this study was to explore the effects of three surface-functionalized (carboxylated, plain, and aminated) polystyrene microplastics on nano-TiO toxicity across two trophic levels containing Chlorella sp.

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Micro/nanoplastics are ubiquitous in the environment and cause pollution of the aquatic ecosystem, in particular, which is a serious concern worldwide. Micro/nanoplastics can act as a vector for multiple co-contaminants that co-exist in the aquatic environment. Apart from micro/nanoplastics, nanomaterials and pharmaceuticals are other emerging contaminants that can also raise severe problems.

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There has been a significant increased concern of the impact of the toxicity of multiple contaminants in the marine environment. Thus, this study was aimed at determining whether the interaction between nano-TiO and Cr(VI) would modulate their toxic effects with the marine crustacean, Artemia salina. Nano-TiO agglomerated in artificial sea water (ASW) and readily formed micron-sized particles that settled down in the medium.

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Pollutants such as n-TiO and tetracycline enter the marine environment through various sources starting from their production until disposal. Hence, it is vital to determine the interactive effect of one pollutant with the other when they coexist in the environment. In the present study, the effect of antibiotic - tetracycline (TC) on the toxicity of P25 n-TiO was studied with marine microalgae, Chlorella sp.

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Titanium dioxide nanoparticles (TiO NPs) find applications in our day-to-day life because of unique physicochemical properties. Their release into the aquatic environment poses a possible risk to the organisms. However, the continuing exposure of NPs might reduce their bioavailability to marine organisms owing to aggregation and sedimentation in the aqueous systems thus significantly reducing their toxic impact.

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The use of P25 TiO NPs in consumer products, their release, and environmental accumulation will have harmful effects on the coastal ecosystems. The sensitivity to TiO NPs may vary depending on the structural property and physiological mechanism of algal species. Therefore, the present study investigates the differences in sensitivity of two marine algae, Dunaliella salina and Chlorella sp.

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Article Synopsis
  • * The study investigates how different types of functionalized microplastics affect the toxicity of TiO NPs on marine algae (Chlorella sp.), finding that TiO NPs are significantly toxic while microplastics have minimal toxicity at higher concentrations.
  • * Results indicate that certain microplastics, like plain and aminated polystyrene, enhance the toxicity of TiO NPs through oxidative stress, while carboxylated polystyrene microplastics may reduce toxicity due to aggregation in the marine environment. *
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The recent increase in nanoparticle (P25 TiO NPs) usage has led to concerns regarding their potential implications on environment and human health. The food chain is the central pathway for nanoparticle transfer from lower to high trophic level organisms. The current study relies on the investigation of toxicity and trophic transfer potential of TiO NPs from marine algae Dunaliella salina to marine crustacean Artemia salina.

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Clinical use of camptothecin (CPT) is hindered due to its poor water and oil solubility, active lactone ring instability and non-targeted toxicity. Recently we reported formulation of camptothecin microemulsions with increased solubility for the improved treatment of breast cancer. In this research chitosan stabilized camptothecin nanoemulsions (CHI-CPT-NEs) were formulated improve the cancer targeting efficiency of CPT.

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Choline, a type of Vitamin B, is an important nutrient in the human body and is involved in key metabolic pathways. Abnormal levels of choline leads to diseased conditions. The levels of choline and its associated compounds are found to be elevated in triple negative breast cancer (TNBC) patients.

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