Dysbiosis of the Beneficial Gut Bacteria in Patients with Parkinson's Disease from India.

Objectives: Recent advancement in understanding neurological disorders has revealed the involvement of dysbiosis of the gut microbiota in the pathophysiology of Parkinson's disease (PD). We sequenced microbial DNA using fecal samples collected from PD cases and healthy controls (HCs) to evaluate the role of gut microbiota.

Methods: Full-length bacterial 16S rRNA gene sequencing of fecal samples was performed using amplified polymerase chain reaction (PCR) products on the GridION Nanopore sequencer.

Activity of Two Cefepime-Based Novel Combinations, Cefepime/Taniborbactam and Cefepime/Zidebactam, against Carbapenemase-Expressing Collected in India.

In recent times, discovery efforts for novel antibiotics have mostly targeted carbapenemase-producing Gram-negative organisms. Two different combination approaches are pertinent: β-lactam-β-lactamase inhibitor (BL/BLI) or β-lactam-β-lactam enhancer (BL/BLE). Cefepime combined with a BLI, taniborbactam, or with a BLE, zidebactam, has been shown to be promising.

Following the Indian Immigrant: adoption of westernization results in a western gut microbiome and an increased risk of inflammatory bowel diseases.

Indians who migrate to westernized countries such as Canada, the USA, and the UK are at an increased risk of developing inflammatory bowel disease (IBD). While the underlying aetiology of IBD remains unclear, a gut microbiome, i.e.

Mono- and Bimetallic Nanoparticles for Catalytic Degradation of Hazardous Organic Dyes and Antibacterial Applications.

In the present work, gold (Au), silver (Ag), and copper (Cu) based mono- and bimetallic NPs are prepared using a cost-effective facile wet chemical route. The pH for the synthesis is optimized in accordance with the optical spectra and supported by the finite difference time domain simulation studies. FESEM and TEM micrographs are used to analyze the morphology of the prepared nanoparticles.

Exploring the multifactorial aspects of Gut Microbiome in Parkinson's Disease.

Advanced research in health science has broadened our view in approaching and understanding the pathophysiology of diseases and has also revolutionised diagnosis and treatment. Ever since the establishment of Braak's hypothesis in the propagation of alpha-synuclein from the distant olfactory and enteric nervous system towards the brain in Parkinson's Disease (PD), studies have explored and revealed the involvement of altered gut microbiota in PD. This review recapitulates the gut microbiome associated with PD severity, duration, motor and non-motor symptoms, and antiparkinsonian treatment from recent literature.

Microbiome Profiling of Enterotoxigenic Escherichia coli (ETEC) Carriers Highlights Signature Differences between Symptomatic and Asymptomatic Individuals.

Enterotoxigenic Escherichia coli (ETEC) is an important cause of diarrhea in children in low- and middle-income countries (LMICs). However, large-scale pathogen burden studies in children have identified ETEC in the guts of both symptomatic patients and controls. The factors that influence this balance are poorly understood, but it is postulated that the gut microbiome may play a role in either resistance or progression to disease.

Profile of Helicobacter pylori cagA &vacA genotypes and its association with the spectrum of gastroduodenal disease.

Purpose: Globally, H. pylori virulence factors cagA and vacA genotypes and its variation is leading to the austere form of the gastroduodenal disease. Our objectives were to detect H.

High primary resistance to metronidazole and levofloxacin, and a moderate resistance to clarithromycin in isolated from Karnataka patients.

Background: Due to increased prevalence of antimicrobial resistance worldwide and more importantly the resistance patterns vary between different geographical regions, it is important to survey local antibiotic resistance profile to provide physicians with more informed drug choices to better treat infection. To our knowledge, this is the first study to examine the prevalence of antimicrobial resistance of in Karnataka state of South India.

Results: A total of 113 strains were isolated from gastric biopsies and tested: 81.

O6 gastroenteritis in a patient with lupus nephritis - a report from coastal Karnataka, South India.

Introduction: O1 strains are responsible for pandemics of cholera and major epidemics in the world. All the remaining non-O1/non-O139 strains are less virulent and are responsible for sporadic cases of gastroenteritis. These non-O1/non-O139 serogroups have more than 200 somatic antigens, and mostly lack cholera toxin and toxin co-regulated pilus encoding genes.

Draft Genome Sequences of 42 Isolates from Rural Regions of South India.

is a successful human gastric pathogen that is associated with the development of gastric cancer. The draft genome sequences of 42 clinical strains isolated from South Indian rural populations will provide further insights into the evolution and genetic makeup of Indian strains.

in Dyspepsia: Phenotypic and Genotypic Methods of Diagnosis.

Background: affects almost half of the world's population and therefore is one of the most frequent and persistent bacterial infections worldwide. is associated with chronic gastritis, ulcer disease (gastric and duodenal), mucosa-associated lymphoid tissue lymphoma, and gastric cancer. Several diagnostic methods exist to detect infection and the option of one method or another depends on various genes, such as availability, advantages and disadvantages of each method, monetary value, and the age of patients.

, an emerging pathogen causing acute gastroenteritis: a Case Report.

is a motile, Gram-negative, oxidase-positive, halophilic bacteria first defined in 1977. It is ubiquitously present in marine environments and is one of the 11 non-cholera species pathogenic in humans, which can lead to human gastroenteritis and extra-intestinal manifestations. A 73-year-old female patient was admitted to the hospital with acute gastroenteritis after consumption of seafood, which later by microbiological investigations was confirmed as , a member of the family .

Emergence and serovar profiling of non-typhoidal Salmonellae (NTS) isolated from gastroenteritis cases-A study from South India.

Human infection with non-typhoidal Salmonella (NTS) serovars is often a neglected and undiagnosed infection in the developing world. Invasive NTS is now being established as having a new and emerging pathogenic role. There is not sufficient data on the prevalence of NTS serovars and their antibiotic susceptibility pattern from India.