Oxygenation imaging in deep tissue with X-Ray luminescence computed tomography (XLCT).

Oxygenation concentration of tissue is an important factor in culturing stem cells and in studying the therapy response of cancer cells. The hypoxia bone marrow is the site to harbor cancer cells. Thus, direct high-resolution measurements of molecular 𝑂 would provide powerful means of monitoring cultured stem cells and therapied cancer cells.

Identification and characterization of degradation products of indacaterol using liquid chromatography/mass spectrometry.

Indacaterol (IND), 5-[2-[(5,6-Diethyl-2,3-dihydro-1H-inden-2-yl)amino]-1-hydroxyethyl]-8-hydroxyquinolin-2(1H)-one, is an active pharmaceutical ingredient (API) which is used to treat chronic obstructive pulmonary disease (COPD). We followed the International Council for Harmonization (ICH) guide lines to study the degradation behavior of IND under various stress conditions. Stressed degradation of the drug was performed under hydrolytic (alkaline, acidic and neutral), photolytic, oxidative and thermal conditions.