Phytoceutical Isoquercitrin and Ethanolic Extracts from Pequi (Caryocar coriaceum Wittm) Reverse Alcohol Withdrawal-Induced Anxiety in Adult Zebrafish (Danio rerio).

Pharmacotherapy in Alcohol Withdrawal Syndrome (AWS), which is a mental disorder, generally involves benzodiazepines due to their action via GABA, but their side effects, such as excessive sedation, mental confusion and risk of dependence, are considerable. It is important to investigate the anxiolytic potential of plants such as Caryocar coriaceum, due to the presence of secondary metabolic compounds, such as isoquercitrin, capable of promoting the reduction of anxiety during AWS. We evaluated the anxiolytic-like potential of ethanolic extracts from the leaves (EEPL) and pulp (EEPP) of C.

Confirmatory validation of the transgender health care humanization scale.

Background: Despite the critical importance of humanized healthcare for transgender individuals, no existing measures specifically assess care humanization for this population. The Transgender Health Care Humanization Scale (THcH Scale) was developed to address this gap, yet it initially lacked confirmatory validation. This study validates the Transgender THcH scale for evaluating healthcare providers' sensitivity towards transgender patients.

Utilization of biodiesel residue through efficient microwave-assisted synthesis of carbon quantum dots: A versatile nanomaterial for environmental remediation.

The rapid expansion of the biodiesel industry has substantially increased crude glycerol residue (CG) production, creating sustainability and economic challenges due to surplus glycerol generation. Conventional purification methods are costly and environmentally demanding, necessitating innovative strategies to utilize this residue effectively. This study innovates by exploring the microwave-assisted synthesis of carbon dots (CDs) from CG, exemplifying a shift toward sustainable biodiesel production by transforming the residue into a multifunctional material.

Association between malnutrition-inflammation score (MIS) and quality of life in elderly hemodyalisis patients.

Introduction: The malnutrition-inflammation process is one of the main causes of morbidity and mortality in patients with chronic kidney disease (CKD), influencing quality of life. The aim of this study was to identify the inflammatory and nutritional status of elderly hemodialysis (HD) and its association with quality of life.

Methods: This study was carried out in health services in three different cities.

Trend in the epidemiological risk of leprosy in the state of Goiás-Brazil between 2010 and 2021.

Objective: To analyze trends in epidemiological risk of leprosy in Goiás state, Brazil, and its health macro-regions, between 2010 and 2021.

Method: This is a time series analysis of the composite leprosy epidemiological risk index in Goiás. We used cases held on the Notifiable Health Conditions Information System for calculating indicators separately and risk, classified as high, medium, low and very low.

Carcinoma Cuniculatum, a Rare Variant of Oral Squamous Cell Carcinoma: Presentation of Five Clinical Cases and Review of the Literature.

Background: Oral carcinoma cuniculatum (CC) is a rare variant of squamous cell carcinoma. It exhibits a locally aggressive behaviour, and its histopathology poses a diagnostic challenge, as it can be mistaken for other conditions. We present five cases of oral CC treated at our institution and conduct a comprehensive review of the current literature.

Liraglutide Pretreatment Does Not Improve Acute Doxorubicin-Induced Cardiotoxicity in Rats.

Doxorubicin is an effective drug for cancer treatment; however, cardiotoxicity limits its use. Cardiotoxicity pathophysiology is multifactorial. GLP-1 analogues have been shown to reduce oxidative stress and inflammation.

Quality of life and associated factors for community health workers in the context of the COVID-19 pandemic in northeastern Brazil.

In this study, we evaluated the quality of life (QoL) and associated factors of community health workers (CHWs) in different urban settings as a contributor to the preparedness of Brazilian primary care for future sanitary emergencies. The sample included 1935 CHWs from 4 state capitals and 4 inland municipalities in northeastern Brazil. Information was collected on QoL (WHOQOL-BREF), work routines, sociodemographics, direct and indirect exposure to violence, general self-efficacy, social support (MSPSS), mental health (SRQ-20) and coronavirus anxiety.

[Tuberculosis mortality trends and the correlation with the socio-demographic index in Brazil between 2010 and 2019].

The scope of this article is to analyze the trend of the standardized mortality rate (SMR) for tuberculosis and its correlation with the developmental status in Brazil. An ecological time series study was conducted to analyze data of deaths from tuberculosis reported between 2005 and 2019 in all states. Data were extracted from the Mortality Information System, the Brazilian Institute of Geography and Statistics, and the Global Burden of Disease study.

Cervids as Sentinels for Rickettsia spp. in Portugal.

Cervids are highly exposed to ticks, however, their role in the life cycle of these rickettsiae has not been fully elucidated. Given the expanding distribution and growing population of deer species in Portugal, coupled with their direct and indirect interactions with humans during hunting, it becomes crucial to explore their role as sentinels and potential reservoirs of Rickettsia. The present investigation aimed to detect and evaluate exposure to Rickettsia in free-living deer from Portugal.

SNX27: A trans-species cognitive modulator with implications for anxiety and stress susceptibility.

Sorting Nexin 27 (SNX27) is a brain-enriched endosome-associated cargo adaptor that shapes excitatory control, being relevant for cognitive and reward processing, and for several neurological conditions. Despite this, SNX27's role in the nervous system remains poorly explored. To further understand SNX27 function, we performed an extensive behavioral characterization comprising motor, cognitive and emotional dimensions of SNX27 mice.

Potential of the Blue Calm® food supplement in the treatment of alcohol withdrawal-induced anxiety in adult zebrafish (Danio rerio).

Alcohol use disorder (AUD) is characterized by a set of behavioral, cognitive, nutritional, and physiological phenomena derived from the uncontrolled use of alcoholic beverages. There are cases in which AUD is associated with anxiety disorder, and when untreated, it requires careful pharmacotherapy. Blue Calm® (BC) is a food supplement indicated to aid restorative sleep, which has traces of medicinal plant extracts, as well as myo-inositol, magnesium bisglycinate, taurine, and L-tryptophan as its main chemical constituents.

lignocellulolases and lipases produced in Macaúba residue and use of the enzymatic extract in the degradation of textile dyes.

Agro-industrial residue and textile effluents have caused environmental damage to soil and water bodies. The production of fungal enzymes using agro-industrial residues and the use of these enzymes in the degradation of textile dyes can be a viable alternative to reduce these environmental damages. is a white rot fungus with high nutritional value that produces edible mushrooms and enzymes of commercial interest.

Predicting the distribution and abundance of abandoned, lost or discarded fishing gear (ALDFG) in the deep sea of the Azores (North Atlantic).

Abandoned, lost, or discarded fishing gear (ALDFG), represents a significant percentage of the global plastic pollution, currently considered one of the major sources from sea-based activities. However, there is still limited understanding of the quantities of ALDFG present on the seafloor and their impacts. In this study, data on the presence of ALDFG was obtained from a large archive of seafloor video footage (351 dives) collected by different imaging platforms in the Azores region over 15 years (2006-2020).

Tetraspanin CD82 Associates with Trafficking Vesicle in Muscle Cells and Binds to Dysferlin and Myoferlin.

Tetraspanins organize protein complexes at the cell membrane and are responsible for assembling diverse binding partners in changing cellular states. Tetraspanin CD82 is a useful cell surface marker for prospective isolation of human myogenic progenitors and its expression is decreased in Duchenne muscular dystrophy (DMD) cell lines. The function of CD82 in skeletal muscle remains elusive, partly because the binding partners of this tetraspanin in muscle cells have not been identified.

Self-rated health among adolescents from vulnerable areas and their sociodemographic, lifestyle and contextual factors: A multilevel analysis.

Purpose: Understanding self-rated health in young people can help orient global health actions, especially in regions of social vulnerability. The present study analysed individual and contextual factors associated with self-rated health in a sample of Brazilian adolescents.

Design And Methods: Cross-sectional data from 1272 adolescents (aged 11-17; 48.

Simulation of self-modulated laser wakefield acceleration using few TW in downramp injection and ionization injection regimes.

Simulations of transitional self-modulated laser wakefield acceleration driven by laser pulses of a few terawatts are discussed, comparing a downramp-based injection regime with an ionization injection regime. We demonstrate that a configuration using an gas target and a laser pulse of ∼75 with ∼2 peak power is a good alternative as a high repetition rate system that produces electrons of many tens of MeV, pC charge, and emittance of the order of 1 mm mrad.

Femtosecond laser-plasma dynamics study by a time-resolved Mach-Zehnder-like interferometer.

Side-view density profiles of a laser-induced plasma were measured by a home-built, time-resolved, Mach-Zehnder-like interferometer. Due to the pump-probe femtosecond resolution of the measurements, the plasma dynamics was observed, along with the pump pulse propagation. The effects of impact ionization and recombination were evidenced during the plasma evolution up to hundreds of picoseconds.

Metalliferous atmospheric settleable particulate matter action on the fat snook fish (Centropomus parallelus): Metal bioaccumulation, antioxidant responses and histological changes in gills, hepatopancreas and kidneys.

Metallic smoke released by steel industries is constitute by a mixture of fine and gross particles containing metals, including the emerging ones, which sedimentation contaminates soil and aquatic ecosystems and put in risk the resident biota. This study determined the metal/metalloids in the atmospheric settleable particulate matter (SePM, particles >10 μm) from a metallurgical industrial area and evaluated metal bioconcentration, antioxidant responses, oxidative stress, and the histopathology in the gills, hepatopancreas and kidneys of fat snook fish (Centropomus parallelus) exposed to different concentrations of SePM (0.0, 0.

Understanding the Seasonal Effect of Metabolite Production in L. Leaves through a Concatenated MS- and NMR-Based Metabolomics Approach.

L. (Combretaceae) is a medicinal plant that is part of the Brazilian biodiversity; this plant is popularly used for the treatment of a wide range of diseases. To better understand the chemical composition of in different seasons, we conducted a thorough study using LC-MS and NMR data analysis techniques.

Beans comsumption can contribute to the prevention of cardiovascular disease.

Cardiovascular diseases (CVD) are the major cause of global mortality, accounting for 31% of deaths worldwide. Healthy eating habits based on the consumption of bioactive molecules present in plant-based diets can contribute to the prevention of CVD. In this context, the consumption of common beans (Phaseolus vulgaris L.

Small terrestrial mammals (Rodentia and Soricomorpha) along a gradient of forest anthropisation (reserves, managed forests, urban parks) in France.

Background: Understanding the relationships between wildlife biodiversity and zoonotic infectious diseases in a changing climate is a challenging issue that scientists must address to support further policy actions. We aim at tackling this challenge by focusing on small mammal-borne diseases in temperate forests and large urban green spaces. Small mammals are important reservoirs of zoonotic agents, with a high transmission potential for humans and domestic animals.

High prevalence of cardiovascular disease and risk factors among type 2 diabetes patients followed in a hospital setting in Portugal: The PICT2RE observational study.

Introduction And Objectives: Portugal is a country with a high prevalence of type 2 diabetes (T2D) and cardiovascular disease (CVD). The prevalence of CVD and cardiovascular (CV) risk factors among T2D patients followed in hospitals in Portugal is not known. The primary objective of this study was to assess the prevalence of CVD and CV risk factors among T2D patients in a hospital setting in Portugal.

Fear of cancer recurrence among Brazilian patients with cancer: Translation and cultural adaptation of FCR4/7 and FCRI-SF measures.

Objective: Fear of cancer recurrence or progression (FCR) is considered one of the most common unmet needs among patients with cancer. This study sought to translate and evaluate the psychometric properties of the Fear of Cancer Recurrence scale (FCR4/7) and Fear of Cancer Recurrence Inventory-Short Form (FCRI-SF).

Methods: This study involved three phases: (1) translation and cultural adaptation of the FCR4/7 and FCRI-SF measures, (2) validity and reliability testing of the Portuguese version of these measures, and (3) examining patient's perceptions of these measures.