Association of Poly (ADP-Ribose) Polymerase 1 Variants with Oral Squamous Cell Carcinoma Susceptibility in a South Indian Population.

Background: Oral cancers account for approximately 2% of all cancers diagnosed each year; however, the vast majority (80%) of the affected individuals are smokers whose risk of developing a lesion is five to nine times greater than that of non-smokers. Tobacco smoke contains numerous carcinogens that cause DNA damage, including oxidative lesions that are removed effectively by the base-excision repair (BER) pathway, in which poly (ADP-ribose) polymerase 1 (PARP-1), plays key roles. Genetic variations in the genes encoding DNA repair enzymes may alter their functions.

Permanent mandibular incisor with multiple anomalies - report of a rare clinical case.

Permanent mandibular central incisor is rarely affected by tooth shape anomalies of crown and root. Co-occurrence of multiple anomalies in a permanent mandibular central incisor is extremely rare. This paper reports an unusual concurrent combination of multiple dental anomalies affecting both the crown and root of a permanent mandibular left central incisor - talon cusp, dens invaginatus, short root anomaly and macrodontia -, which has not previously been reported together.

Survey of mesiodens and its characteristics in 2500 children of Davangere city, India.

Aim: The aim of the present study is to report the prevalence of mesiodens and its characteristics and also to present 25 cases with 27 mesiodentes in 2500 children in Davangere city, India.

Materials And Methods: A survey of 2500 children examined in the Department of Paediatric Dentistry was conducted. Their ages ranged from 3 to 12 years.