Publications by authors named "Vidyavathi Maravajhala"
Present study aims to prepare and evaluate niacin microspheres. Niacin-ethyl cellulose microspheres were prepared by water-in-oil-in-oil double emulsion solvent diffusion method. Spherical, free flowing microspheres having an entrapment efficiency of 72% were obtained.
View Article and Find Full Text PDFRole of human liver microsomes in in vitro metabolism of drugs-a review.
Appl Biochem Biotechnol
March 2010
Drug metabolism studies are essential and necessary during the evaluation of drugs. This review discusses the in vitro human liver models to estimate the drug metabolic fates in vivo. Different approaches are provided and emphasis is placed on the potential of human liver microsomes for drug metabolism and inhibition studies.
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- Researchers examined how different microbes could break down dextromethorphan (DXM), a substance metabolized by the enzyme CYP 2D6 in humans, to compare microbial and human metabolism.
- Eight different microbes were tested, with Saccharomyces cerevisiae (NCIM 3090) showing significant ability to convert DXM into dextrorphan, its major active metabolite in humans.
- The study suggests that Saccharomyces cerevisiae can serve as an effective in vitro model for studying DXM metabolism and for future pharmacological and toxicological research.
Drug metabolism studies constitute an important and necessary step in the evaluation of drug efficacy and safety. In vivo drug metabolism studies suffer from many disadvantages. Hence there is a rise in validation of in vitro microbial models.
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