Structure-Activity Relationship of Truncated 4'-Selenonucleosides: A Adenosine Receptor Activity and Binding Selectivity.

This study explored the impact of structural modifications on truncated 4'-selenonucleosides as ligands for the A adenosine receptor (AR). We synthesized and evaluated a series of these compounds for their binding affinities, functional activities, and structural interactions by using computational modeling. The SAR study revealed that all compounds exhibited selective and notable hAAR binding, among which ( = 5.