Publications by authors named "Vidur Kailash"
Tumor Suppressor MicroRNAs in Clinical and Preclinical Trials for Neurological Disorders.
Pharmaceuticals (Basel)
March 2024
Cancers and neurological disorders are two major types of diseases in humans. We developed the concept called the "Aberrant Cell Cycle Disease (ACCD)" due to the accumulating evidence that shows that two different diseases share the common mechanism of aberrant cell cycle re-entry. The aberrant cell cycle re-entry is manifested as kinase/oncoprotein activation and tumor suppressor (TS) inactivation, which are associated with both tumor growth in cancers and neuronal death in neurological disorders.
View Article and Find Full Text PDFAims: The objective of this study was to assess the effect of HER2-directed therapy (HER2-Tx) on peripheral vasoreactivity and its correlation with cardiac function changes and the additive effects of anthracycline/cyclophosphamide (AC) therapy and baseline cardiovascular risk.
Methods And Results: Single-centre, prospective cohort study of women with newly diagnosed stage 1-3 HER2-positive breast cancer undergoing HER2-Tx +/- AC. All participants underwent baseline and 3-monthly evaluations with Endo-Peripheral Arterial Tonometry (Endo-PAT), vascular biomarkers [C-type natriuretic peptide (CNP) and neuregulin-1 beta (NRG-1β)], and echocardiography.
Article Synopsis
- Researchers are focusing on controlling oxygen levels in engineered systems to study their effects on cell behavior, especially under hypoxic conditions.
- A specialized hydrogel allows for precise manipulation of oxygen concentrations, enabling uniform cell behavior analysis and the study of vasculogenesis (new blood vessel formation) under different oxygen levels.
- The findings highlight the role of cyclic AMP signaling and cell adhesion molecules in endothelial cell clustering in response to oxygen deprivation, paving the way for better understanding of cellular processes in various biological contexts like regeneration and disease.
The efficiency of shotgun proteomic analysis is dependent on the reproducibility of the peptide cleavage process during sample preparation. To generate rapid and useful metrics for peptide cleavage efficiency, as in enzymatic or chemical cleavage, SPACEPro was developed to evaluate efficiency and reproducibility of protein cleavage in peptide samples following data-dependent analysis by mass spectrometry. SPACEPro analyzes samples at the peptide-spectrum match (PSM), peptide, and protein levels to provide a comprehensive representation of the overall sample processing to peptides.
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