Bibliometric and scientometric analysis on biomarkers and molecular mechanisms for physical frailty and sarcopenia.

Introduction: The influence of physical frailty and sarcopenia (PFS) on the well-being of older people and continuous pressure on the healthcare systems has prompted a research on the pathophysiology and molecular mechanisms of these conditions. Nonetheless some biomarkers have been suggested as potential markers for PFS none of them have been shown to highlight the complex nature of PFS, which reveals that there is a need for an understanding of the possible biomarker candidates. The aim of this study was to identify the current research hotspots, status, and trends in the field of biomarkers and molecular mechanisms for PFS.

An experience- and preference-based EQ-5D-3L value set derived using 18 months of longitudinal data in patients who sustained a fracture: results from the ICUROS.

Introduction: EQ-5D-3L preference-based value sets are predominately based on hypothetical health states and derived in cross-sectional settings. Therefore, we derived an experience-based value set from a prospective observational study.

Methods: The International Costs and Utilities Related to Osteoporotic fractures Study (ICUROS) was a multinational study on fragility fractures, prospectively collecting EQ-5D-3L and Time trade-off (TTO) within two weeks after fracture (including pre-fracture recall), and at 4, 12, and 18 months thereafter.

Associations between Physical Function, Bone Density, Muscle Mass and Muscle Morphology in Older Men with Sarcopenia: A Pilot Study.

It is thought that muscle and bone interact only on a biomechanical level, however, some research is now emerging that links bone and muscle on a cellular level. The aim of this study was to explore associations between physical function, muscle mass and bone density in community-dwelling elderly men with sarcopenia. A secondary goal was to analyze if muscle morphology was associated with bone density and physical functioning.

Validation of the Lithuanian version of sarcopenia-specific quality of life questionnaire (SarQoL).

Purpose: The aim of this study was to translate and culturally adapt the SarQoL questionnaire into Lithuanian and investigate its main psychometric properties.

Methods: A cross-sectional study was performed on community-dwelling Lithuanian people aged ≥ 60 years. The revised criteria of the European Working Group on Sarcopenia in Older People were used.

Bone metabolism genes variation and response to bisphosphonate treatment in women with postmenopausal osteoporosis.

Introduction: Long-term treatment is used in patients with osteoporosis, and bisphosphonates (BPs) are the most commonly prescribed medications. However, in some patients this therapy is not effective, cause different side effects and complications. Unfortunately, at least one year is needed to identify and confirm an ineffectiveness of BPs therapy on bone mineral density (BMD).

Standard error of measurement and smallest detectable change of the Sarcopenia Quality of Life (SarQoL) questionnaire: An analysis of subjects from 9 validation studies.

Objectives: The Sarcopenia Quality of Life (SarQoL) questionnaire, a sarcopenia-specific patient-reported outcome measure, evaluates quality of life with 55 items. It produces 7 domain scores and 1 overall quality of life score, all between 0 and 100 points. This study aims to contribute to the interpretation of the SarQoL scores by calculating the standard error of measurement (SEM) and smallest detectable change (SDC) in a sample of subjects from 9 studies.

Reliability and Validity of the Lithuanian Version of CASP-19: A Quality of Life Questionnaire for the Elderly.

Ageing is associated with several physical, psychological, and behavioral changes. These changes are closely related with general health problems and quality of life in old age. The CASP-19 multidimensional instrument was specially designed to measure quality of life in the elderly.

Vitamin D Level and Activities of Daily Living in Octogenarians: Cross-Sectional Study.

Introduction: Despite the growing number of octogenarians, little is known about their vitamin D status and activities of daily living (ADL) relations.

Objective: The aim of this study was to investigate peculiarities of vitamin D and ADL and to assess their relations in octogenarians.

Methods: A cross-sectional study was performed at the National Osteoporosis Centre located in Vilnius, Lithuania.

Association of Vitamin D Receptor Gene Variation With Osteoporosis Risk in Belarusian and Lithuanian Postmenopausal Women.

Vitamin D receptor (VDR) is one of the main mediators of vitamin D biological activity. VDR dysfunction might substantially contribute to development of postmenopausal osteoporosis (PMO). Numerous studies have revealed the effects of several gene variants on osteoporosis risk, although significant variation in different ethnicities have been suggested.

Quality of life after hip, vertebral, and distal forearm fragility fractures measured using the EQ-5D-3L, EQ-VAS, and time-trade-off: results from the ICUROS.

Introduction: The International Costs and Utilities Related to Osteoporotic fractures Study is a multinational observational study set up to describe the costs and quality of life (QoL) consequences of fragility fracture. This paper aims to estimate and compare QoL after hip, vertebral, and distal forearm fracture using time-trade-off (TTO), the EuroQol (EQ) Visual Analogue Scale (EQ-VAS), and the EQ-5D-3L valued using the hypothetical UK value set.

Methods: Data were collected at four time-points for five QoL point estimates: within 2 weeks after fracture (including pre-fracture recall), and at 4, 12, and 18 months after fracture.

Evaluation of bone mineral density in postmenopausal women with alterations of the mandible cortical bone.

Objective: Menopause affects the bone quality and quantity of jaw bone. The aim of this study was to evaluate the validity of mandibular cortical measurements in the diagnosis of low bone mineral density (BMD) in postmenopausal women.

Methods: A total of 113 postmenopausal women (mean age 63.

Self-reported consequences and healthcare costs of falls among elderly women.

Background And Objective: Although the falls in elderly people lead to serious health consequences, the economic burden is underestimated. The aim of this study was to calculate the medical costs of fall consequences in elderly women.

Materials And Methods: Women aged 65 years and older were interviewed by phone recording the consequences and healthcare procedures related to every fall sustained during the previous 12 months.

Association Between Polymorphisms of VDR, COL1A1, and LCT genes and bone mineral density in Belarusian women with severe postmenopausal osteoporosis.

BACKGROUND AND OBJECTIVE. Variation of osteoporosis in the population is the result of an interaction between the genotype and the environment, and the genetic causes of osteoporosis are being widely investigated. The aim of this study was to analyze the association between the polymorphisms of the vitamin D receptor (VDR), type I collagen (COL1A1), and lactase (LCT) genes and severe postmenopausal osteoporosis as well as bone mineral density (BMD).

Incidence and direct hospitalisation costs of hip fractures in Vilnius, capital of Lithuania, in 2010.

Background: Few epidemiological data on hip fractures were previously available in Lithuania. The aim of this study was to estimate the incidence and hospital costs of hip fractures in Vilnius in 2010.

Methods: Data were collected from the medical charts of all patients admitted to hospitals in Vilnius (population, 548,835) due to new low-energy trauma hip fracture, during 2010.

Relationship between mandibular cortical bone height and bone mineral density of lumbar spine.

Unlabelled: The aim of this study was to evaluate the association between lumbar spine bone mineral density and mandible cortical bone height at the mental foramen and at the angle of the jaw.

Patients And Methods: A total of 130 women living in Lithuania, were examined. None of the participants were known to have endocrine, metabolic or skeletal disorders.

Differences in WHOQOL-100 domain scores in Parkinson's disease and osteoarthritis.

Background: The aim was to compare health-related quality of life (QOL) in patients with Parkinson's disease, osteoarthritis, and persons of a matched control group.

Material/methods: The study was done in 178 patients (94 men and 84 women, 54 with Parkinson's disease and 58 with osteoarthritis) and 66 age- and sex-matched controls. The patients were randomly selected from a register of community health maintenance organizations.

[The impact of subclinical vertebral fractures on health-related quality of life in women with osteoporosis].

The aim of the study was to evaluate the impact of subclinical vertebral fractures on health-related quality of life in women with postmenopausal osteoporosis. A disease-specific instrument, Quality of Life Questionnaire of the European Foundation for Osteoporosis (QUALEFFO-41) questionnaire, developed to measure quality of life in patients with osteoporosis, was used. A total of 120 postmenopausal women who came for consultation were examined.

[Bone mineral density in healthy Lithuanian women].

Objective: The purposes of this investigation were to determine spine and femoral bone mineral density for a representative sample of healthy women of Lithuanian descent and to compare these results with US/European reference data.

Methods: We randomly selected 1200 women aged 20-79 years from Lithuanian population registers. Densitometry of the lumbar spine and left proximal femur was determined by a LUNAR DPX-IQ system (Lunar corp.