Glucose reduced nano-Se mitigates Cu-induced ROS by upregulating antioxidant genes in zebrafish larvae.

This study compares the therapeutic efficiency of bovine serum albumin-stabilized selenium nanoparticles in reducing oxidative stress and improving cellular health. The nanoparticles were synthesized using mussel-extracted selenium with two reducing agents: d-glucose and orange. Inductively coupled plasma-optical emission spectroscopy and X-ray diffraction analyses confirmed the presence of selenium.

In Silico Molecular Docking of Phytochemicals: Targeting Key Biomarkers in Oral Cancer.

Background: Oral cancer is the sixth most common cancer occurring anywhere in the globe. Cancers of the mouth are caused by tobacco and alcohol overuse, and also between pre-malignancy and full-fledged malignancy. In order to avoid the onset of illness, proper cleanliness of the mouth is important.

Exploring the Role of β-Sitosterol, Genistein, and Emodin in Periodontal Regeneration.

The incidence rate of periodontal diseases is high, which affects the quality of life of patients, and is one of the main causes of adult dentition defects. Periodontal diseases cause the periodontal intraosseous defect. If not treated in time, it can lead to alveolar bone resorption and defect, periodontal attachment loss, teeth loosening, and complete tooth loss.

Unlocking the Therapeutic Benefits of Artemisia Annua: A Comprehensive Overview of its Medicinal Properties.

Artemisia annua L., also referred to as sweet wormwood, sweet annie, sweet sagewort, and annual wormwood (Chinese: qngho), is a species of wormwood native to temperate Asia but naturalised worldwide. It is a member of the Asteraceae family.

Electrophysiological Changes in Simulated Atrial Sheets Due to Sympathetic Hyperactivity.

The electrophysiological changes in the atria due to sympathetic hyperactivity during episodes of psychological distress are unclear. We simulated sympathetic hyperactivity by rapidly pacing atrial sheets with increasing adrenergic stimulation (AS) spatial densities. We measured changes to the electrophysiological parameters of atrial sheets, such as captured waves (CW), conduction speed (CS), slope of depolarization (SoD), isolated conduction channels (ICC), and wavefront ratio (WFR), using videos and action potential signals.

Historical Demography and Species Distribution Models Shed Light on Speciation in Primates of Northeast India.

Past climate change is one of the important factors influencing primate speciation. Populations of various species could have risen or declined in response to these climatic fluctuations. Northeast India harbors a rich diversity of primates, where such fluctuations can be implicated.

Establishing reproductive seasons for the conservation of the critically endangered Kashmir red deer Cervus Hanglu.

Ungulates living in seasonal environments adopt complex life history strategies to cope with pronounced temporal and spatial variability in environmental conditions and resource availability. Understanding the reproductive strategies of slow-breeding mountain ungulates and the associated stress, particularly in the context of human- and climate-induced changes, is crucial to devising effective long-term management and conservation strategies. We investigated the patterns in reproductive seasonality and stress in hangul in Kashmir Himalaya, India.

Role of TM7 in the Oral Microbiome and its Implications for Periodontal Disease: A Systematic Review.

Periodontal disease, a prevalent oral health condition, involves a complex microbial community. Advanced sequencing technologies have enabled in-depth studies of the oral microbiome, focusing on specific bacterial taxa like TM7. This systematic review analyzes the role of TM7 in the oral microbiome and its implications for periodontal disease.

Blue-LED assisted Photodegradation kinetics of rhodamine-6G dye, enhanced anticancer activity and cleavage of plasmids using Au-ZnO nanocomposite.

The plasmonic metal doping on the UV-active metal oxide nanoparticle turns the resultant plasmonic metal-metal oxide (PMMO) into visible light active and upon exogenous illumination the photogenerated energetic charge carriers and the generated reactive oxygen species (ROS, e.g. ·OH and O ) authoritatively enhances its biological and catalytic activity.

Design and Development of Portable Body Composition Analyzer for Children.

Objectives: The aim of this study was (i) to design and develop a portable BCA device for measuring body composition parameters such as body weight, body fat (BF) %, total body water (TBW), fat-free mass (FFM), muscle mass (MM), and bone mass (BM); (ii) to validate the developed portable BCA with the Tanita MC 980 MA BCA device.

Methods: For this current study, two hundred healthy and obese subjects, whose ages ranged from 8 to 12 years (8.4 ± 1.

Unraveling the Augmented Field Emission Performance of Molybdenum Disulfide-Praseodymium Sulfide (MoS@PrS) Heterostructure: A Combined Experimental and First Principles-Based Study.

The molybdenum disulfide-praseodymium sulfide (MoS-PrS) heterojunctions are optimally synthesized through a sophisticated three-step procedure. Initially, MoS rods are synthesized using the micellar route followed by a solid-state reaction, forming well-defined structures. Subsequently, PrS nanoparticles are synthesized using the same method.

Computer-aided diagnosis of early-stage Retinopathy of Prematurity in neonatal fundus images using artificial intelligence.

Retinopathy of Prematurity (ROP) is a retinal disorder affecting preterm babies, which can lead to permanent blindness without treatment. Early-stage ROP diagnosis is vital in providing optimal therapy for the neonates. The proposed study predicts early-stage ROP from neonatal fundus images using Machine Learning (ML) classifiers and Convolutional Neural Networks (CNN) based pre-trained networks.

Greenly Synthesized Conducting Polymer Nanotunnels with Metal-Hydroxide Nanobundles in Single Dais for Unmitigated Water Oxidation.

Electrochemical water splitting required efficient electrocatalysts to produce clean hydrogen fuel. Here, we adopted greenway coprecipitation (GC) method to synthesize conducting polymer (CP) nanotunnel network affixed with luminal-abluminal CoNi hydroxides (GC-CoNiCP), namely, GC-CoNiCP, GC-CoNiCP, and GC-CoNiCP. The active catalyst, GC-CoNiCP/GC, has low oxygen evolution reaction (OER) overpotential (307 mV) and a smaller Tafel slope (47 mV dec) than IrO (125 mV dec).

A Case of Idiopathic Twenty-Nail Dystrophy.

In children, nail diseases can be either congenital or acquired, with an occurrence rate of 3 to 11% in the pediatric population. In both fingers and toes, rough, accentuated linear ridges of the nails are referred to as trachyonychia. This condition most commonly occurs in childhood, with a higher prevalence in males.

Edward Jenner: A Beacon of Hope in the Age of Disease.

Edward Jenner, born in 1749 in Berkeley, Gloucestershire, England is widely recognized as the pioneer of the smallpox vaccine, a breakthrough that paved the way for the eventual eradication of the disease. This article traces Jenner's journey from his early education and apprenticeship under renowned surgeon John Hunter to his groundbreaking work on vaccination. Jenner's keen observations led him to hypothesize that cowpox could provide immunity against smallpox, which he confirmed through an experiment in 1796.

A Syndrome Affecting All Five Sense Organs: A Rare Congenital Disorder of Kabuki Makeup Syndrome With Multiple Pre-auricular Skin Tags.

Kabuki syndrome is an autosomal dominant disorder characterized by distinct facial features, including long palpebral fissures, a short columella with a flat, broad nasal tip, ptosis, and cleft lip/palate. The syndrome was named for the resemblance of the facial features to the make-up worn by traditional Kabuki performers. We report the case of a 10-month-old female infant admitted for cleft palate repair.

Effects of spatially dense adrenergic stimulation to rotor behaviour in simulated atrial sheets.

Sympathetic hyperactivity via spatially dense adrenergic stimulation may create pro-arrhythmic substrates even without structural remodelling. However, the effect of sympathetic hyperactivity on arrhythmic activity, such as rotors, is unknown. Using simulations, we examined the effects of gradually increasing the spatial density of adrenergic stimulation (AS) in atrial sheets on rotors.

RA-XTNet: A Novel CNN Model to Predict Rheumatoid Arthritis from Hand Radiographs and Thermal Images: A Comparison with CNN Transformer and Quantum Computing.

The aim and objective of the research are to develop an automated diagnosis system for the prediction of rheumatoid arthritis (RA) based on artificial intelligence (AI) and quantum computing for hand radiographs and thermal images. The hand radiographs and thermal images were segmented using a UNet++ model and color-based k-means clustering technique, respectively. The attributes from the segmented regions were generated using the Speeded-Up Robust Features (SURF) feature extractor and classification was performed using k-star and Hoeffding classifiers.

Impact of Nadi Shuddhi Pranayama on Apnea Hypopnea Index, Respiratory Distress Index, and Oxygen Desaturation Index Among Adolescents With Sleep Apnea Syndrome.

Background Sleep apnea syndrome has gained significant recognition over the last decade as a potential cause of substantial childhood morbidity. This study aimed to evaluate the impact of the Apnea Hypopnea Index (AHI), Respiratory Distress Index (RDI), and Oxygen Desaturation Index (ODI) among adolescents with sleep apnea syndrome. Objectives The objective of this study is to compare the impact of Nadi Shuddhi Pranayama with routine treatment modalities on the AHI, RDI, and ODI among adolescents with sleep apnea syndrome.

F-Net: Follicles Net an efficient tool for the diagnosis of polycystic ovarian syndrome using deep learning techniques.

The study's primary objectives encompass the following: (i) To implement the object detection of ovarian follicles using you only look once (YOLO)v8 and subsequently segment the identified follicles using a hybrid fuzzy c-means-based active contour technique. (ii) To extract statistical features and evaluate the effectiveness of both machine learning (ML) and deep learning (DL) classifiers in detecting polycystic ovary syndrome (PCOS). The research involved a two different dataset in which dataset1 comprising both normal (N = 50) and PCOS (N = 50) subjects, dataset 2 consists of 100 normal and 100 PCOS affected subjects for classification.

Endoscopic Advances in the Diagnosis and Management of Gastroesophageal Reflux Disease.

Gastroesophageal reflux disease (GERD) is one of the most common diseases that occurs secondary to failure of the antireflux barrier system, resulting in the frequent and abnormal reflux of gastric contents to the esophagus. GERD is diagnosed in routine clinical practice based on the classic symptoms of heartburn and regurgitation. However, a subset of patients with atypical symptoms can pose challenges in diagnosing GERD.

Unlocking estrogen receptor: Structural insights into agonists and antagonists for glioblastoma therapy.

Glioblastoma (GBM), a malignant brain tumor originating in glial cells, is one of the most common primary brain malignancies, affecting one in 100,000 people, typically in the frontal lobe. Estrogens, like estradiol-17 (E2), significantly influence GBM progression, metastasis, and angiogenesis. Estrogen receptors (ERs) are crucial in signal transduction and physiology, making them potential therapeutic targets.

Effectiveness of a suction device for containment of pathogenic aerosols and droplets.

Background: As the global community begins recovering from the COVID-19 pandemic, the challenges due to its aftermath remain. This health crisis has highlighted challenges associated with airborne pathogens and their capacity for rapid transmission. While many solutions have emerged to tackle this challenge, very few devices exist that are inexpensive, easy to manufacture, and versatile enough for various settings.

Loss of Chromosome Y in Neuroblastoma Is Associated With High-Risk Disease, 11q-Deletion, and Telomere Maintenance.

Neuroblastoma (NB) is a heterogeneous childhood cancer with a slightly higher incidence in boys than girls, with the reason for this gender disparity unknown. Given the growing evidence for the involvement of loss of the Y chromosome (LoY) in male diseases including cancer, we investigated Y chromosome status in NB. Male NB tumor samples from a Swedish cohort, analyzed using Cytoscan HD SNP-microarray, were selected.

Metalloproteins structural and functional insights into immunological patterns.

Metalloproteins play a crucial role in regulating different aspects of the immune system in humans. They have various functions in immunity, including recognizing and presenting antigens, aiding in the movement and effectiveness of immune cells, and facilitating interactions between the host and pathogens. Understanding how these proteins work can help us develop new methods to control the immune response in different diseases.