Enhancing cancer care with improved checkpoint inhibitors: a focus on PD-1/PD-L1.

The emergence of checkpoint inhibitors targeting the PD-1/PD-L1 axis marks a paradigm shift in cancer therapy, offering a novel avenue for enhancing patient outcomes. This review examines the structural and functional dynamics of PD-1 and PD-L1 while exploring the clinical implications of current PD-1/PD-L1 monoclonal antibodies. Highlighting recent advancements, this paper delves into the promising results from combination therapies that present a multifaceted attack on tumor progression.

A Comparative Analysis of Methods of Endmember Selection for Use in Subpixel Classification: A Convex Hull Approach.

Mixed pixels in aerial and satellite images are common, especially near the boundaries of two or more discrete classes; that is, they tend to occur at the transitional region between two classes. Ideally, to decipher the mixed pixel, a soft classification is performed compared to a hard- or a per-pixel classification. Soft or subpixel classification is carried out where the fractional cover of the LULC contained within a pixel is derived.