Publications by authors named "Victorri-Vigneau C"

Introduction And Aims: EMONO (equimolar oxygen-nitrous oxide mixture) is widely used in dentistry to achieve sedation for dental care. In addition, pure nonmedical nitrous oxide (N2O) has become a very popular psychoactive substance among health students. Thus, for dental students, the perception of a same substance, N2O, which can either be used as medicine in the form of EMONO in their daily practice, or consumed illegally for recreational purposes in the form of pure nonmedical N2O, is of concern.

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Addictovigilance is a French health monitoring system, composed of 13 centres distributed across the national territory, that aims to monitor cases of abuse, misuse, or use disorders related to psychoactive substances. Fulfilling these missions requires a regional network that ensures efficient information flow, dissemination to health authorities, and subsequent downward communication to prevent risks. This was illustrated through the example of nitrous oxide misuse.

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Article Synopsis
  • Cannabidiol (CBD) is a cannabis compound with potential medical benefits, and this study aimed to assess its usage among patients in substance use disorder treatment.
  • Out of 183 patients, 38.2% reported using CBD in the past year, but 63% had recently stopped, mainly due to ineffectiveness and cost concerns.
  • CBD users tend to be younger with psychiatric comorbidities and prefer inhalation methods, and the study highlights the importance for clinicians to regularly ask about CBD use due to potential drug interactions.
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Purpose: Equimolar oxygen-nitrous oxide mixture (EMONO) is considered as a reference for dental care in children. Completion of dental treatment has usually been used as a criterion to assess EMONO treatment. However, other patient-reported outcomes are needed.

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The French Addictovigilance Network has been using data from the French Heath insurance since the late 1990s to assess prescription drug abuse. In this narrative review, we illustrate the inputs of pharmacoepidemiology in addictovigilance based on the experience of the French Addictovigilance Network. The review focuses on pharmacoepidemiology using the French National Health Data System.

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Background: In the context of the opioid overdose crisis, understanding the barriers to seeking, attaining and remaining in treatment for patients with opioid use disorder (OUD) is a public health issue. To date, very few studies have assessed the "self-stigma" (i.e.

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  • Opioid use disorder (OUD) remains a global health issue, with relapse being heavily influenced by comorbid conditions such as ADHD.
  • Nearly half of the patients with OUD reported having ADHD in childhood, and about two-thirds continued to experience symptoms into adulthood, which negatively impacted treatment outcomes.
  • Factors like early onset of OUD, lower education, and high impulsivity were linked to poor results; ADHD's effect on treatment outcome was mediated by impulsive emotional responses rather than direct influence.
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  • Cannabinoid hyperemesis syndrome involves severe nausea and vomiting linked to heavy cannabis use, raising concerns about cannabidiol (CBD) as a potential trigger due to its rising popularity in legalized areas.
  • A case study of a 32-year-old male who switched from cannabis to CBD revealed recurrent vomiting episodes related to CBD use, despite no cannabis consumption; hot showers temporarily alleviated symptoms.
  • Current hypotheses about the cause of cannabis-induced cyclic vomiting suggest possible mechanisms involving THC accumulation or CBD's effects on specific receptors, highlighting the need for further research into CBD's health impacts.
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Background: Long-term use of opioids does not result in significant clinical improvement and has shown more adverse than beneficial effects in chronic pain conditions. When opioids cause more adverse effects than benefits for the patient, it may be necessary to initiate a process of deprescribing.

Aim: To explore the perceptions of French pain physicians regarding the process of opioid deprescribing in patients experiencing chronic non-cancer and to generate an understanding of the barriers and levers to the deprescribing process.

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Objective: For several years, both the French Addictovigilance Network and French health authorities have consistently emphasized the need to provide opioid users with take-home naloxone (THN), the specific antidote for opioid overdoses. In March 2022, the French Health Authority recommended systematically assessing the appropriateness of prescribing THN to all opioid users, regardless of the context, and identified 8 high-risk situations. However, at present, THN distribution remains limited, particularly among primary care healthcare professionals.

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Introduction: Polypharmacy in patients with advanced cancer represents a major public health problem, leading to risk of iatrogenesis, decrease of quality of life and increase of healthcare costs. In the field of geriatrics, health policies have been developed to address polypharmacy through the use of deprescribing tools. Recently, palliative care initiatives have been introduced, yet these have not fully considered the specificities of this population, particularly their perceptions.

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Background: Chronic use of cannabis is associated with an increased risk of psychosocial, mental and physical health impairments. Sociohealth institutions reach a very limited proportion of cannabis users in need of treatment. Using data collected from festival attendees, this study aimed to estimate the prevalence of dependent cannabis users and to characterize cannabis dependence.

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Background: In many countries, nitrous oxide is used in a gas mixture (EMONO) for short-term analgesia. Cases of addiction, with significant misuse, have been reported in hospitalized patients. Patients suffering from sickle cell disease (SCD) could represent a high-risk population for substance use disorder (SUD) due to their significant pain crisis and repeated use of EMONO.

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Article Synopsis
  • * The study involved analyzing health data from two groups: a "COVID-19 crisis cohort" (2020-2021) and a "control cohort" (2018-2019), identifying different patterns of medication use among these populations through various analytical techniques.
  • * Three clusters of new psychotropic drug users emerged during the pandemic, highlighting shifts in treatment initiation timelines and usage patterns, which indicates changes in mental health needs and prescribing practices during this time.
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Background: Opioid-related mortality is a rising public health concern in France, where opioids were in 2021 implicated in 75% of overdose deaths. Opioid substitution treatment (OST) was implicated in almost half of deaths related to substance and drug abuse. Although naloxone could prevent 80% of these deaths, there are a number of barriers to the distribution of take-home naloxone (THN) among opioid users in France.

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Objective: A large body of literature has examined the links between the use of dopamine replacement therapy (DRT) in Parkinson's disease (PD) and the development of "impulsive-compulsive behaviors (ICBs)." Little is known regarding the link between the development of ICBs and health-related quality of life (HRQOL). We aimed to explore the factors that are associated with poorer HRQOL, especially in relation to DRT-induced ICBs, in a sample of PD patients.

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  • The study aimed to evaluate antipsychotic treatment sequences prior to clozapine initiation, as it’s often prescribed later than recommended after two failed treatments.
  • Researchers used data from the French National Health Insurance to analyze treatment patterns among new clozapine users diagnosed with schizophrenia or schizoaffective disorder during 2017-2018.
  • Findings revealed 1191 treatment trials among 287 individuals, with distinct clusters identified: younger "less treated" individuals, "more treated" individuals using combinations of medications, and "treatment-stable" older individuals, indicating a need for further research into barriers to earlier clozapine use.
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Background: Deprescribing benzodiazepines and related drugs (BZDR) is a challenge due to a lack of time on physicians' part, a lack of involvement of other health professionals, and the need for adapted tools. This study is based on primary care collaboration, by evaluating the effectiveness of a joint intervention between general practitioners and community pharmacists on the implementation of BZDR deprescribing in older adults.

Methods: This is a cluster randomized controlled trial in which each cluster will be formed by a physician-pharmacist pair.

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Objectives: Proton pump inhibitors (PPIs) are among the most commonly prescribed medications. The aim of this study was to assess the appropriateness of prescribing PPIs in the palliative care unit on admission and during hospitalisation to determine the applicability of deprescribing recommendations.

Methods: A monocentric observational study was conducted over a 6-month period in 2020 in a university palliative care unit.

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Aim: EMONO is an equimolar mixture of oxygen and nitrous oxide. Studies investigating its anxiolytic effect mostly used behavioral scales for assessing anxiolysis in children during dental care. Observing this effect objectively in a pediatric population could be very interesting.

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Introduction: Nitrous oxide has become over the last few years a public health problem in many countries. France has a dedicated health monitoring system dedicated to the surveillance of the abuse, dependence and consequences associated with the use of psychoactive substances coordinated by the French National Agency for the Safety of Medicines and Health Products.We present the French national survey of nitrous oxide.

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Article Synopsis
  • Illicit substance use at music festivals has changed over the years, leading to the implementation of the OCTOPUS survey to better understand drug use patterns among attendees.
  • Conducted between July 2017 and July 2018 at 13 festivals in France, the survey collected data from 383 participants to analyze drug use prevalence and classify user profiles.
  • The results showed that 82% of participants reported drug use, with two main profiles identified: "no/low polysubstance use," primarily using classic stimulants, and "moderate/extensive polysubstance use," which included a broader range of substances, indicating the need for improved harm reduction strategies.
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