HIF-2α-dependent induction of miR-29a restrains T1 activity during T cell dependent colitis.

Metabolic imbalance leading to inflammatory hypoxia and stabilization of hypoxia-inducible transcription factors (HIFs) is a hallmark of inflammatory bowel diseases. We hypothesize that HIF could be stabilized in CD4 T cells during intestinal inflammation and alter the functional responses of T cells via regulation of microRNAs. Our assays reveal markedly increased T cell-intrinsic hypoxia and stabilization of HIF protein during experimental colitis.

Methodological and reporting quality of systematic reviews referenced in the clinical practice guideline for pediatric high-blood pressure.

Objective: To examine the quality of evidence supporting the Clinical Practice Guideline for Screening and Management of High Blood Pressure in Children and Adolescents.

Methods: Methodological and reporting quality of systematic reviews in the Key Action Statements, Consensus Opinions, and in the reference list were assessed using AMSTAR and The PRISMA checklist.

Results: For the systematic reviews within the American Academy of Pediatrics' Guideline as a whole (n = 27), a mean of 47.