Publications by authors named "Victoria Sinnett"
Article Synopsis
- KORTUC, a treatment combining hydrogen peroxide and sodium hyaluronate, shows promise in reducing hypoxic conditions in tumors after being injected directly into them, potentially improving cancer treatment outcomes.
- In tests using human tumor models, KORTUC led to a notable decrease in hypoxia markers and increased reactive oxygen species levels, indicating enhanced oxygen availability in cancerous tissues.
- If successful in ongoing clinical trials, KORTUC could transform radiation therapy for various cancers, particularly those where low oxygen levels limit treatment effectiveness.
Acceleration-Based Kalman Tracking for Super-Resolution Ultrasound Imaging In Vivo.
IEEE Trans Ultrason Ferroelectr Freq Control
December 2023
Article Synopsis
- - Super-resolution ultrasound (SRUS) uses microbubbles to visualize blood vessel structures and flow at a very small scale but faces challenges in accurately tracking these bubbles due to issues like cardiac movement and high densities of bubbles.
- - This study introduces a new tracking method that incorporates an acceleration-based model into a Kalman filtering system, showing improved performance in simulations and real human breast tumor images, particularly in true positive rates and reducing false negatives.
- - The new method also enhances the accuracy of blood vessel reconstruction compared to traditional techniques and provides additional diagnostic information through the generation of spatial speed gradient maps from the tracked bubbles' acceleration data.
Background: De-escalation of axillary surgery for lymph node (LN) positive breast cancer is facilitated by marking involved nodes which, when removed with sentinel nodes constitute risk-adapted targeted axillary dissection (TAD). Whether after chemotherapy or for primary surgery, selected patients with biopsy-proven involvement of nodes may be eligible for axillary conservation. Likewise, impalpable recurrence or stage 4 patients with localised axillary disease may benefit.
View Article and Find Full Text PDFBackground: Guide-wire localisation remains the most commonly used technique for localisation of impalpable breast lesions in the UK. One alternative is magnetic seed localisation. We aimed to investigate patient and clinician satisfaction in two consecutive cohorts, describe re-excision and positive margin rates, and explore reasons for positive margins and the implications for localisation techniques.
View Article and Find Full Text PDFPurpose: Hydrogen peroxide (HO) plays a vital role in normal cellular processes but at supraphysiological concentrations causes oxidative stress and cytotoxicity, a property that is potentially exploitable for the treatment of cancer in combination with radiation therapy (RT). We report the first phase 1 trial testing the safety and tolerability of intratumoral HO + external beam RT as a novel combination in patients with breast cancer and exploratory plasma marker analyses investigating possible mechanisms of action.
Methods And Materials: Twelve patients with breast tumors ≥3 cm (surgically or medically inoperable) received intratumoral HO with either 36 Gy in 6 twice-weekly fractions (n = 6) or 49.