Publications by authors named "Victoria Sidoroff"
Article Synopsis
- Multiple system atrophy (MSA) is a neurodegenerative disease that leads to symptoms like parkinsonism and ataxia, but its genetic causes are not well understood and treatment options are limited to supportive care.
- A comprehensive study involving the whole genome sequencing of nearly 900 MSA patients and over 7,000 controls discovered four key genetic risk factors associated with the disease.
- The research identified potential susceptibility genes and provided insights into how genetic variations influence gene expression in brain cells, offering a valuable resource for further studies on similar diseases.
Introduction: Gait and mobility impairment are pivotal signs of parkinsonism, and they are particularly severe in atypical parkinsonian disorders including multiple system atrophy (MSA) and progressive supranuclear palsy (PSP). A pilot study demonstrated a significant improvement of gait in patients with MSA of parkinsonian type (MSA-P) after physiotherapy and matching home-based exercise, as reflected by sensor-based gait parameters. In this study, we aim to investigate whether a gait-focused physiotherapy (GPT) and matching home-based exercise lead to a greater improvement of gait performance compared with a standard physiotherapy/home-based exercise programme (standard physiotherapy, SPT).
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- The study aimed to explore sex-related differences in the clinical presentation and progression of multiple system atrophy (MSA) using literature and a retrospective cohort analysis.
- A total of 46 publications were reviewed, revealing comparable survival rates between men and women, though some suggested women might have an advantage due to less severe symptoms at onset.
- Findings from a cohort analysis showed that women were more likely to experience depression and use specific medications, while men had higher occurrences of severe orthostatic hypotension and supine hypertension, emphasizing the need for sex consideration in MSA treatment and research.
Objective: Emotional processing is a core feature of social interactions and has been well studied in patients with idiopathic Parkinson's disease (PD), albeit with contradictory.
Results: . However, these studies excluded patients with atypical parkinsonism, such as multiple system atrophy (MSA).
Multiple system atrophy (MSA) is a rare, adult-onset, progressive neurodegenerative disorder with major diagnostic challenges. Aiming for a better diagnostic accuracy particularly at early disease stages, novel Movement Disorder Society criteria for the diagnosis of MSA (MDS MSA criteria) have been recently developed. They introduce a neuropathologically established MSA category and three levels of clinical diagnostic certainty including clinically established MSA, clinically probable MSA, and the research category of possible prodromal MSA.
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- Study Background
- : The research focuses on a six-generation family from North Bavaria with confirmed cases of multiple system atrophy (MSA) and Parkinson's disease (PD), contrasting the commonly held belief that MSA is a sporadic disorder.
- Findings
- : Neuropathological examinations revealed that the index case had cerebellar variant MSA, while a cousin exhibited both Lewy body disease and tau pathology, supporting the idea of a hereditary link to parkinsonism.
- Genetic Analysis
- : Despite thorough genetic testing, no known hereditary causes for their conditions were found, suggesting the possibility of undiscovered genetic factors contributing to the neurodegenerative disease cluster observed in the family.
Without any disease-modifying treatment strategy for multiple system atrophy (MSA), the therapeutic management of MSA patients focuses on a multidisciplinary strategy of symptom control. In the present review, we will focus on state of the art treatment in MSA and additionally give a short overview about ongoing randomized controlled trials in this field.
View Article and Find Full Text PDFMultiple system atrophy is a rapidly progressive and fatal neurodegenerative disorder. While numerous preclinical studies suggested efficacy of potentially disease modifying agents, none of those were proven to be effective in large-scale clinical trials. Three major strategies are currently pursued in preclinical and clinical studies attempting to slow down disease progression.
View Article and Find Full Text PDFDrug abuse may damage basal ganglia that are essential for planning and execution of movements. We report about the case of a 38-year old patient with ischemic lesions of the basal ganglia presenting with bilateral painful dystonia and parkinsonism caused by polyintoxication. Dronabinol resulted in improvement of pain and gait disturbance, suggesting a novel therapeutic strategy in these challenging patients.
View Article and Find Full Text PDFPurpose: The diagnosis of probable multiple system atrophy relies on the presence of severe cardiovascular or urogenital autonomic failure. Erectile dysfunction is required to fulfil the latter criterion in men, whereas no corresponding item is established for women. In this study, we aimed to investigate sexual dysfunction in women with multiple system atrophy.
View Article and Find Full Text PDFBackground: The approval of monoclonal antibodies for prevention of migraine has revolutionized treatment for patients. Oral preventatives are still considered first line treatments as head-to-head trials comparing them with antibodies are lacking.
Methods: The main purpose of this study was to provide a comparative overview of the efficacy of three commonly prescribed migraine preventative medication classes.
Article Synopsis
- Gait impairment is a major issue in parkinsonian syndromes, with increased variability linked to instability and fall risk.
- The study compared gait variability at different walking speeds among patients with multiple system atrophy (MSA), idiopathic Parkinson's disease (PD), and older adult controls using sensor-based analysis.
- Results indicated that MSA patients exhibited greater gait variability across all speeds compared to controls and PD patients, particularly in swing time and stride length, pointing to significant postural instability in the MSA group.