Publications by authors named "Victoria Serpas Higbie"
Unlabelled: Secondary endpoints (SEP) provide crucial information in the interpretation of clinical trials, but their features are not yet well understood. Thus, we sought to empirically characterize the scope and publication rate of SEPs among late-phase oncology trials. We assessed SEPs for each randomized, published phase III oncology trial across all publications and ClinicalTrials.
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- Neoadjuvant immune checkpoint blockade (IO) shows promise for treating patients with deficient mismatch repair (dMMR) colorectal cancer (CRC), leading to significant pathological response rates.
- A study analyzed 38 patients who underwent IO, finding that 45% had complete endoscopic responses and 23% had complete radiographic responses, with greater responses observed after more than four cycles of treatment.
- Discrepancies were common between imaging and endoscopy results, even when patients achieved pathological complete remission, highlighting the need for better clinical response evaluation methods.
Background: Immune checkpoint blockade (ICB) has improved outcomes for patients with microsatellite instability high (MSI-H)/deficient mismatch repair (dMMR) tumors. However, not all MSI-H/dMMR patients will exhibit the same ICB efficacy. Previous studies suggest that concomitant antibiotic use while receiving ICB may result in poorer outcomes.
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