Publications by authors named "Victoria Sephton"
Study Question: What is the association between serum progesterone levels on the day of frozen embryo transfer (FET) and the probability of live birth in women undergoing different FET regimens?
Summary Answer: Overall, serum progesterone levels <7.8 ng/ml were associated with reduced odds of live birth, although the association between serum progesterone levels and the probability of live birth appeared to vary according to the route of progesterone administration.
What Is Known Already: Progesterone is essential for pregnancy success.
Article Synopsis
- This study investigates the link between serum progesterone levels and the success of frozen embryo transfers (FET) in women trying to conceive.
- By reviewing existing research, it finds that higher progesterone levels (below 10 ng/mL) significantly improve ongoing pregnancy rates and reduce miscarriage risks, particularly when using vaginal progesterone and blastocyst embryos.
- The authors suggest that a certain level of progesterone is crucial for embryo implantation, and they recommend more clinical trials to see if higher doses of progesterone can enhance FET outcomes for women with low levels.
We wished to determine whether the interval between surgical retrieval of epididymal and testicular spermatozoa in obstructive azoospermia and their subsequent use in intracytoplasmic sperm injection (ICSI) has an effect on their fertilizing capacity and pregnancy rates in patients undergoing ICSI. This was a retrospective review of 164 consecutive cycles of ICSI in partners of men undergoing surgical sperm retrieval for obstructive azoospermia. Seventy-three cycles used fresh testicular spermatozoa; in 35 cycles ICSI was performed within 4 hours of sperm retrieval, and in 38 cycles spermatozoa were incubated overnight before ICSI.
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