Publications by authors named "Victoria S Yakimakha"
Article Synopsis
- A limited number of innovative antibacterial agents are being developed to effectively target critical Gram-negative bacteria resistant to current treatments, with endolysins showing promise due to their unique action against these pathogens.
- The study uses a multidisciplinary approach including genetic engineering, structural analysis, and various formulations of the engineered endolysin LysECD7-SMAP, which are tested for effectiveness in preclinical models of infections such as sepsis and pneumonia.
- Results indicate that LysECD7-SMAP is effective against multiple drug-resistant bacteria, and in vivo studies confirm the efficacy of its formulated dosage forms, along with insights into how it interacts with bacterial cell walls.
Endolysin-based therapeutics are promising antibacterial agents and can successfully supplement the existing antibacterial drugs array. It is specifically important in the case of Gram-negative pathogens, e.g.
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